Cholic acid
Cholic acid is a lipid of Sterol Lipids (ST) class. Cholic acid is associated with abnormalities such as Cholestasis, Intrahepatic Cholestasis, Atherosclerosis, Diabetes and cholesterol gallstones. The involved functions are known as Homeostasis, Enterohepatic Circulation, Proliferation (morphologic abnormality), Process and Cell Proliferation. Cholic acid often locates in Hepatic, Cytoplasmic matrix, Membrane, Protoplasm and Tissue membrane. The associated genes with Cholic acid are CYP27A1 gene, ABCB11 gene, NR5A2 gene, SLC10A2 gene and SLC10A1 gene. The related lipids are ursocholic acid, Steroids, Cholestenes, Cholestanes and cholanic acid.
References related to abnormalities published in J. Biol. Chem.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 10867000 | J. Biol. Chem. | 2000 | Hunt MC et al. | The peroxisome proliferator-activated receptor alpha (PPARalpha) regulates bile acid biosynthesis. |
| 21680746 | J. Biol. Chem. | 2011 | Liaset B et al. | Nutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome. |
| 14766742 | J. Biol. Chem. | 2004 | del Castillo-Olivares A et al. | The role of alpha1-fetoprotein transcription factor/LRH-1 in bile acid biosynthesis: a known nuclear receptor activator that can act as a suppressor of bile acid biosynthesis. |
| 11535594 | J. Biol. Chem. | 2001 | Zhang M and Chiang JY | Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression. |