Lysophosphatidylcholine

Lysophosphatidylcholine is a lipid of Glycerophospholipids (GP) class. Lysophosphatidylcholine is associated with abnormalities such as Ischemia, Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Fatty Liver and Atherosclerosis. The involved functions are known as Inflammation, antagonists, Signal Transduction, Signal Pathways and Saturated. Lysophosphatidylcholine often locates in Body tissue, Head, integral to membrane, Membrane and Extracellular. The associated genes with Lysophosphatidylcholine are RHOA gene, Homologous Gene, GPR4 gene, GPR68 gene and TRPV2 gene. The related lipids are Nonesterified Fatty Acids, lysophosphatidylethanolamine, Lysophosphatidylcholines, Phosphatidylserines and 25-hydroxycholesterol. The related experimental models are Knock-out and Disease model.

References related to functions published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
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26945070	J. Biol. Chem.	2016	Quek DQ et al.	Structural Insights into the Transport Mechanism of the Human Sodium-dependent Lysophosphatidylcholine Transporter MFSD2A.
23897815	J. Biol. Chem.	2013	Jiang S et al.	Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosis.
22511767	J. Biol. Chem.	2012	Li Z et al.	Lysophosphatidylcholine acyltransferase 3 knockdown-mediated liver lysophosphatidylcholine accumulation promotes very low density lipoprotein production by enhancing microsomal triglyceride transfer protein expression.
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15927955	J. Biol. Chem.	2005	Ikeno Y et al.	Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor.
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12183451	J. Biol. Chem.	2002	van der Luit AH et al.	Alkyl-lysophospholipid accumulates in lipid rafts and induces apoptosis via raft-dependent endocytosis and inhibition of phosphatidylcholine synthesis.
12124392	J. Biol. Chem.	2002	Kim YJ et al.	Group V phospholipase A2 induces leukotriene biosynthesis in human neutrophils through the activation of group IVA phospholipase A2.
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11042169	J. Biol. Chem.	2001	Cieslik K et al.	Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma /Janus kinase 2/MEK-1-dependent pathway.
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10196168	J. Biol. Chem.	1999	Martens JS et al.	A modification of apolipoprotein B accounts for most of the induction of macrophage growth by oxidized low density lipoprotein.
9774454	J. Biol. Chem.	1998	Biwa T et al.	Induction of murine macrophage growth by oxidized low density lipoprotein is mediated by granulocyte macrophage colony-stimulating factor.
9614091	J. Biol. Chem.	1998	Cieslik K et al.	Transcriptional regulation of endothelial nitric-oxide synthase by lysophosphatidylcholine.
9506985	J. Biol. Chem.	1998	Wong JT et al.	Lysophosphatidylcholine stimulates the release of arachidonic acid in human endothelial cells.
9188470	J. Biol. Chem.	1997	Pillarisetti S et al.	Endothelial cell heparanase modulation of lipoprotein lipase activity. Evidence that heparan sulfate oligosaccharide is an extracellular chaperone.
9153219	J. Biol. Chem.	1997	Fang X et al.	Lysophosphatidylcholine stimulates activator protein 1 and the c-Jun N-terminal kinase activity.
8910311	J. Biol. Chem.	1996	Sakai M et al.	The scavenger receptor serves as a route for internalization of lysophosphatidylcholine in oxidized low density lipoprotein-induced macrophage proliferation.
8663471	J. Biol. Chem.	1996	Pete MJ and Exton JH	Purification of a lysophospholipase from bovine brain that selectively deacylates arachidonoyl-substituted lysophosphatidylcholine.
7493959	J. Biol. Chem.	1995	Günther-Ausborn S et al.	Inhibition of influenza-induced membrane fusion by lysophosphatidylcholine.
7542654	J. Biol. Chem.	1995	Zembowicz A et al.	Transcriptional induction of endothelial nitric oxide synthase type III by lysophosphatidylcholine.