phosphatidylinositol-4-phosphate

phosphatidylinositol-4-phosphate is a lipid of Glycerophospholipids (GP) class. Phosphatidylinositol-4-phosphate is associated with abnormalities such as Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection and Rhinovirus infection. The involved functions are known as Agent, Signal Transduction, Synthesis, Regulation and Process. Phosphatidylinositol-4-phosphate often locates in Membrane, Tissue membrane, Endosomes, Cytoskeleton and Cell membrane. The associated genes with phosphatidylinositol-4-phosphate are Homologous Gene, Homologous Protein, CDC42 gene, Genome and PIK4CB gene. The related lipids are phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, Phosphatidylserines, phosphatidylinositol 3-phosphate and Total cholesterol.

References related to functions published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
12471042	J. Biol. Chem.	2003	Rajebhosale M et al.	Phosphatidylinositol 4-OH kinase is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells.
24158445	J. Biol. Chem.	2013	Lukacs V et al.	Promiscuous activation of transient receptor potential vanilloid 1 (TRPV1) channels by negatively charged intracellular lipids: the key role of endogenous phosphoinositides in maintaining channel activity.
22942276	J. Biol. Chem.	2012	Shulga YV et al.	Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator.
22745132	J. Biol. Chem.	2012	Bishé B et al.	Role of phosphatidylinositol 4-phosphate (PI4P) and its binding protein GOLPH3 in hepatitis C virus secretion.
22351780	J. Biol. Chem.	2012	Jacquot A et al.	Phosphatidylserine stimulation of Drs2p·Cdc50p lipid translocase dephosphorylation is controlled by phosphatidylinositol-4-phosphate.
19561074	J. Biol. Chem.	2009	Qin Y et al.	Regulation of phosphatidylinositol kinases and metabolism by Wnt3a and Dvl.
19139096	J. Biol. Chem.	2009	Brice SE et al.	Modulation of sphingolipid metabolism by the phosphatidylinositol-4-phosphate phosphatase Sac1p through regulation of phosphatidylinositol in Saccharomyces cerevisiae.
17088255	J. Biol. Chem.	2007	Jeganathan S and Lee JM	Binding of elongation factor eEF1A2 to phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and phosphatidylinositol 4-phosphate generation.
15322077	J. Biol. Chem.	2004	Seifert JP et al.	RhoA activates purified phospholipase C-epsilon by a guanine nucleotide-dependent mechanism.
14766750	J. Biol. Chem.	2004	Wild AC et al.	The p21-activated protein kinase-related kinase Cla4 is a coincidence detector of signaling by Cdc42 and phosphatidylinositol 4-phosphate.
10567424	J. Biol. Chem.	1999	Gonzalez-Agosti C et al.	Interdomain interaction of merlin isoforms and its influence on intermolecular binding to NHE-RF.
10224046	J. Biol. Chem.	1999	Stock SD et al.	SEC14-dependent secretion in Saccharomyces cerevisiae. Nondependence on sphingolipid synthesis-coupled diacylglycerol production.
9478953	J. Biol. Chem.	1998	Willars GB et al.	Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells.