Zaragozic acid A

Zaragozic acid A is a lipid of Polyketides (PK) class. Zaragozic acid a is associated with abnormalities such as Hypercholesterolemia, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity, Atherosclerosis and Infection. The involved functions are known as Anabolism, Sterol Biosynthesis Pathway, isoprenoid biosynthetic process, Biochemical Pathway and Adverse effects. Zaragozic acid a often locates in Endoplasmic reticulum, membrane, viral nucleocapsid location, Cell surface, Hepatic and Membrane. The associated genes with Zaragozic acid A are DPM1 gene, PMM2 gene, STN gene, SLC6A7 gene and Amyloid beta-Protein Precursor. The related lipids are Sterols, Fatty Acids, Membrane Lipids, farnesoic acid and Unilamellar Vesicles. The related experimental models are Mouse Model.

References related to functions published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
10964918	J. Biol. Chem.	2000	Ravid T et al.	The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
14754889	J. Biol. Chem.	2004	Bate C et al.	Squalestatin cures prion-infected neurons and protects against prion neurotoxicity.
21183681	J. Biol. Chem.	2011	Haeuptle MA et al.	Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid.
19903814	J. Biol. Chem.	2010	Vukelic S et al.	Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor.
17483544	J. Biol. Chem.	2007	Brusselmans K et al.	Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation.