apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

References related to functions published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
12609974	J. Biol. Chem.	2003	Mead JR et al.	Interferon-gamma stimulates the expression of the inducible cAMP early repressor in macrophages through the activation of casein kinase 2. A potentially novel pathway for interferon-gamma-mediated inhibition of gene transcription.
10806215	J. Biol. Chem.	2000	Song DH et al.	Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells.
15213223	J. Biol. Chem.	2004	Klampfer L et al.	Oncogenic Ras promotes butyrate-induced apoptosis through inhibition of gelsolin expression.
14602723	J. Biol. Chem.	2004	Way TD et al.	Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway.
22086925	J. Biol. Chem.	2012	Ding J et al.	Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression.
16982614	J. Biol. Chem.	2006	Balasubramanian S et al.	Apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311.
23184958	J. Biol. Chem.	2013	Berim A and Gang DR	The roles of a flavone-6-hydroxylase and 7-O-demethylation in the flavone biosynthetic network of sweet basil.
14993215	J. Biol. Chem.	2004	Kuronuma K et al.	Pulmonary surfactant protein A augments the phagocytosis of Streptococcus pneumoniae by alveolar macrophages through a casein kinase 2-dependent increase of cell surface localization of scavenger receptor A.
11451952	J. Biol. Chem.	2001	Tammi R et al.	Hyaluronan enters keratinocytes by a novel endocytic route for catabolism.
11278484	J. Biol. Chem.	2001	Hanyaloglu AC et al.	Casein kinase II sites in the intracellular C-terminal domain of the thyrotropin-releasing hormone receptor and chimeric gonadotropin-releasing hormone receptors contribute to beta-arrestin-dependent internalization.