rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

References related to functions published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
10336426	J. Biol. Chem.	1999	Chen N et al.	Translocation of protein kinase Cepsilon and protein kinase Cdelta to membrane is required for ultraviolet B-induced activation of mitogen-activated protein kinases and apoptosis.
10383415	J. Biol. Chem.	1999	Reyland ME et al.	Protein kinase C delta is essential for etoposide-induced apoptosis in salivary gland acinar cells.
11598137	J. Biol. Chem.	2001	Wakino S et al.	Peroxisome proliferator-activated receptor gamma ligands inhibit mitogenic induction of p21(Cip1) by modulating the protein kinase Cdelta pathway in vascular smooth muscle cells.
11796722	J. Biol. Chem.	2002	Li B et al.	Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C.
11274209	J. Biol. Chem.	2001	Vancurova I et al.	NF-kappa B activation in tumor necrosis factor alpha-stimulated neutrophils is mediated by protein kinase Cdelta. Correlation to nuclear Ikappa Balpha.
12403780	J. Biol. Chem.	2003	Kim HJ et al.	The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2.
12226102	J. Biol. Chem.	2002	Saito S et al.	Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src.
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12493764	J. Biol. Chem.	2003	Minami T et al.	Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways.
10636851	J. Biol. Chem.	2000	Efimova T and Eckert RL	Regulation of human involucrin promoter activity by novel protein kinase C isoforms.
14514687	J. Biol. Chem.	2003	Ham YM et al.	The c-Jun N-terminal kinase 1 activity is differentially regulated by specific mechanisms during apoptosis.
14594813	J. Biol. Chem.	2004	Ryazanova LV et al.	Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel.
14747473	J. Biol. Chem.	2004	Iwabu A et al.	Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway.
21669868	J. Biol. Chem.	2011	López-Huertas MR et al.	Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytes.
19648576	J. Biol. Chem.	2009	Esper RM and Loeb JA	Neurotrophins induce neuregulin release through protein kinase Cdelta activation.
20639513	J. Biol. Chem.	2010	Lanaspa MA et al.	The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP.
17307743	J. Biol. Chem.	2007	Lu R et al.	Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells.
15767261	J. Biol. Chem.	2005	Hurbin A et al.	Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells.
15618223	J. Biol. Chem.	2005	Amos S et al.	Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells.
16260419	J. Biol. Chem.	2005	Zhao KW et al.	Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK.
15863503	J. Biol. Chem.	2005	Tse SM et al.	Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis.
17158874	J. Biol. Chem.	2007	Burkhart BA et al.	Osmotic stress-dependent repression is mediated by histone H3 phosphorylation and chromatin structure.