Farnesyl diphosphate
Farnesyl diphosphate is a lipid of Prenol Lipids (PR) class. Farnesyl diphosphate is associated with abnormalities such as Dental caries and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Regulation, Process, Signal, Anabolism and inhibitors. Farnesyl diphosphate often locates in peroxisome, Cytoplasmic matrix, Plasma membrane, soluble and Mitochondria. The associated genes with Farnesyl diphosphate are HSD3B1 gene, ABRA gene, MATN1 gene, SEPSECS gene and MBD2 gene. The related lipids are Sterols, 22-hydroxycholesterol, dehydrosqualene, SK&F 104976 and 25-hydroxycholesterol.
References related to functions published in J. Biol. Chem.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 9218438 | J. Biol. Chem. | 1997 | Scholten JD et al. | Synergy between anions and farnesyldiphosphate competitive inhibitors of farnesyl:protein transferase. |
| 10531376 | J. Biol. Chem. | 1999 | Gardner RG and Hampton RY | A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes. |
| 21778231 | J. Biol. Chem. | 2011 | Leichner GS et al. | Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein. |