forskolin

Forskolin is a lipid of Prenol Lipids (PR) class. Forskolin is associated with abnormalities such as Cholestasis, Vocal cord dysfunction familial, Hypothyroidism, Renal tubular disorder and Disintegration (morphologic abnormality). The involved functions are known as Cell Proliferation, Anabolism, mRNA Expression, Agent and Signal. Forskolin often locates in Extracellular, Body tissue, Skin, Tissue membrane and Membrane. The associated genes with forskolin are P4HTM gene, SLC33A1 gene, NR1I2 gene, Genes, Reporter and CYP3A gene. The related lipids are Steroids, steroid sulfate, Fatty Acids, LYSO-PC and Lipopolysaccharides.

References related to functions published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
7673177	J. Biol. Chem.	1995	Withers DJ et al.	Dissociation of cAMP-stimulated mitogenesis from activation of the mitogen-activated protein kinase cascade in Swiss 3T3 cells.
8662906	J. Biol. Chem.	1996	Watabe M et al.	The cooperative interaction of two different signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells.
10383385	J. Biol. Chem.	1999	McVey M et al.	Adenylyl cyclase, a coincidence detector for nitric oxide.
11297520	J. Biol. Chem.	2001	Sapkota GP et al.	Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.
10660591	J. Biol. Chem.	2000	Thommesen L et al.	Regulation of inducible cAMP early repressor expression by gastrin and cholecystokinin in the pancreatic cell line AR42J.
10585462	J. Biol. Chem.	1999	Daniels GM and Amara SG	Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters.
10748000	J. Biol. Chem.	2000	Sjöholm A et al.	Rapid Ca2+ influx and diacylglycerol synthesis in growth hormone-mediated islet beta -cell mitogenesis.
10767293	J. Biol. Chem.	2000	Orellana SA and Marfella-Scivittaro C	Distinctive cyclic AMP-dependent protein kinase subunit localization is associated with cyst formation and loss of tubulogenic capacity in Madin-Darby canine kidney cell clones.
17428796	J. Biol. Chem.	2007	Black SA et al.	Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c-JUN N-terminal kinase.