phytosphingosine

phytosphingosine is a lipid of Sphingolipids (SP) class. Phytosphingosine is associated with abnormalities such as Infection, Nodule, Dehydration, Neuropathy and nervous system disorder. The involved functions are known as Saturated, sphingomyelin synthase activity, Heat-Shock Response, Cell Growth and Apoptosis. Phytosphingosine often locates in Clone, Protoplasm, Mitochondria, soluble and Cytoplasmic matrix. The associated genes with phytosphingosine are SGMS1 gene, BCL2 gene, Chromatin, Homologous Gene and DLEU2 gene. The related lipids are Sphingolipids, inositolphosphorylceramide, Phosphatidylserines, dihydroceramide and Fatty Acids. The related experimental models are Knock-out.

References related to functions published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
9446592	J. Biol. Chem.	1998	Skrzypek MS et al.	Inhibition of amino acid transport by sphingoid long chain bases in Saccharomyces cerevisiae.
9195906	J. Biol. Chem.	1997	Qie L et al.	Identification of a Saccharomyces gene, LCB3, necessary for incorporation of exogenous long chain bases into sphingolipids.
9092515	J. Biol. Chem.	1997	Nagiec MM et al.	Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene.
11468289	J. Biol. Chem.	2001	Chung N et al.	Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae.
11337502	J. Biol. Chem.	2001	Abe M et al.	Yeast 1,3-beta-glucan synthase activity is inhibited by phytosphingosine localized to the endoplasmic reticulum.
10764732	J. Biol. Chem.	2000	Chung N et al.	Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis.
15190065	J. Biol. Chem.	2004	Welsch CA et al.	Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine.
15155728	J. Biol. Chem.	2004	Aoki K et al.	Newly discovered neutral glycosphingolipids in aureobasidin A-resistant zygomycetes: Identification of a novel family of Gala-series glycolipids with core Gal alpha 1-6Gal beta 1-6Gal beta sequences.
15840588	J. Biol. Chem.	2005	Liu K et al.	The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9.
16407254	J. Biol. Chem.	2006	Panwar SL and Moye-Rowley WS	Long chain base tolerance in Saccharomyces cerevisiae is induced by retrograde signals from the mitochondria.
14522966	J. Biol. Chem.	2003	Park MT et al.	Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells.
16141212	J. Biol. Chem.	2005	Sano T et al.	Regulation of the sphingoid long-chain base kinase Lcb4p by ergosterol and heme: studies in phytosphingosine-resistant mutants.
18474589	J. Biol. Chem.	2008	Castro A et al.	Increased resistance of complex I mutants to phytosphingosine-induced programmed cell death.
22277656	J. Biol. Chem.	2012	Montefusco DJ et al.	Sphingoid bases and the serine catabolic enzyme CHA1 define a novel feedforward/feedback mechanism in the response to serine availability.
11056159	J. Biol. Chem.	2001	Jenkins GM and Hannun YA	Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.
22275366	J. Biol. Chem.	2012	Guo L et al.	Connections between sphingosine kinase and phospholipase D in the abscisic acid signaling pathway in Arabidopsis.
21454514	J. Biol. Chem.	2011	Bozna BL et al.	Binding strength and dynamics of invariant natural killer cell T cell receptor/CD1d-glycosphingolipid interaction on living cells by single molecule force spectroscopy.
21330371	J. Biol. Chem.	2011	Guo L et al.	Phosphatidic acid binds and stimulates Arabidopsis sphingosine kinases.
16129666	J. Biol. Chem.	2005	Mare L et al.	APP1 transcription is regulated by inositol-phosphorylceramide synthase 1-diacylglycerol pathway and is controlled by ATF2 transcription factor in Cryptococcus neoformans.