sphingosylphosphorylcholine

sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.

References related to functions published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
7592645	J. Biol. Chem.	1995	Seufferlein T and Rozengurt E	Sphingosylphosphorylcholine activation of mitogen-activated protein kinase in Swiss 3T3 cells requires protein kinase C and a pertussis toxin-sensitive G protein.
7592646	J. Biol. Chem.	1995	Seufferlein T and Rozengurt E	Sphingosylphosphorylcholine rapidly induces tyrosine phosphorylation of p125FAK and paxillin, rearrangement of the actin cytoskeleton and focal contact assembly. Requirement of p21rho in the signaling pathway.
9195933	J. Biol. Chem.	1997	Lai TS et al.	Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase.
7890637	J. Biol. Chem.	1995	Kim S et al.	Sphingolipid-gated Ca2+ release from intracellular stores of endothelial cells is mediated by a novel Ca(2+)-permeable channel.
9668122	J. Biol. Chem.	1998	Rodríguez-Fernández JL and Rozengurt E	Bombesin, vasopressin, lysophosphatidic acid, and sphingosylphosphorylcholine induce focal adhesion kinase activation in intact Swiss 3T3 cells.
11432865	J. Biol. Chem.	2001	Nofer JR et al.	Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids.
15280385	J. Biol. Chem.	2004	Murakami N et al.	G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine.
19910470	J. Biol. Chem.	2010	Kovacs E et al.	Dissociation of calmodulin-target peptide complexes by the lipid mediator sphingosylphosphorylcholine: implications in calcium signaling.
15788404	J. Biol. Chem.	2005	Sakagami H et al.	Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family.