lauric acid

lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.

References related to functions published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
8995277	J. Biol. Chem.	1997	Helvig C et al.	Suicide inactivation of cytochrome P450 by midchain and terminal acetylenes. A mechanistic study of inactivation of a plant lauric acid omega-hydroxylase.
7829524	J. Biol. Chem.	1995	Ramarao MK et al.	Identification by in vitro mutagenesis of the interaction of two segments of C2MstC1, a chimera of cytochromes P450 2C2 and P450 2C1.
9813074	J. Biol. Chem.	1998	Kroetz DL et al.	Peroxisome proliferator-activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes.
11278967	J. Biol. Chem.	2001	Lee JY et al.	Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4.
12764132	J. Biol. Chem.	2003	Okino N et al.	The reverse activity of human acid ceramidase.
12670931	J. Biol. Chem.	2003	Zackova M et al.	Activating omega-6 polyunsaturated fatty acids and inhibitory purine nucleotides are high affinity ligands for novel mitochondrial uncoupling proteins UCP2 and UCP3.
10652339	J. Biol. Chem.	2000	Nakagawa T et al.	Peroxisomal membrane protein Pmp47 is essential in the metabolism of middle-chain fatty acid in yeast peroxisomes and Is associated with peroxisome proliferation.
14966134	J. Biol. Chem.	2004	Lee JY et al.	Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.
19648648	J. Biol. Chem.	2009	Wong SW et al.	Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner.
19398560	J. Biol. Chem.	2009	Smith NJ et al.	The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1.
20097757	J. Biol. Chem.	2010	Lampe JN et al.	Two-dimensional NMR and all-atom molecular dynamics of cytochrome P450 CYP119 reveal hidden conformational substates.
17303577	J. Biol. Chem.	2007	Zhao L et al.	Differential modulation of Nods signaling pathways by fatty acids in human colonic epithelial HCT116 cells.
16120613	J. Biol. Chem.	2005	Kandel S et al.	Cloning, functional expression, and characterization of CYP709C1, the first sub-terminal hydroxylase of long chain fatty acid in plants. Induction by chemicals and methyl jasmonate.