25-Hydroxycholesterol

25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.

References related to functions published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
8810339	J. Biol. Chem.	1996	McGee TP et al.	Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis.
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7744865	J. Biol. Chem.	1995	Yang J et al.	Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution.
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18996837	J. Biol. Chem.	2009	Gale SE et al.	Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions.
18165705	J. Biol. Chem.	2008	Wang PY et al.	The N terminus controls sterol binding while the C terminus regulates the scaffolding function of OSBP.
21343306	J. Biol. Chem.	2011	Jo Y et al.	Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
20406816	J. Biol. Chem.	2010	Hartman IZ et al.	Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets.
20178991	J. Biol. Chem.	2010	Furuita K et al.	Electrostatic interaction between oxysterol-binding protein and VAMP-associated protein A revealed by NMR and mutagenesis studies.
19687008	J. Biol. Chem.	2009	Li H et al.	Hepatocyte nuclear factor 1alpha plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine.
18450749	J. Biol. Chem.	2008	Bowden K and Ridgway ND	OSBP negatively regulates ABCA1 protein stability.
15899885	J. Biol. Chem.	2005	Sun LP et al.	Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.
15213220	J. Biol. Chem.	2004	Demoulin JB et al.	Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins.
11967256	J. Biol. Chem.	2002	Agellon LB et al.	Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice.
11279184	J. Biol. Chem.	2001	Xu Y et al.	Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport.