22-Hydroxycholesterol

22-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22-hydroxycholesterol is associated with abnormalities such as Hypertensive disease, Cardiovascular Diseases, Congestive heart failure, Atherosclerosis and Hypercholesterolemia. The involved functions are known as physiological aspects, Regulation, Anabolism, Metabolic Inhibition and Adjudication. 22-hydroxycholesterol often locates in Body tissue, Blood, Mitochondria, Membrane and Tissue membrane. The associated genes with 22-Hydroxycholesterol are Candidate Disease Gene, ABCA1 gene, CLTC gene, SLC22A1 gene and SLC10A1 gene. The related lipids are Hydroxycholesterols, Lipopolysaccharides, 22-hydroxycholesterol, Fatty Acids and (22R)-22-hydroxycholesterol.

References related to functions published in J. Biol. Chem.


PMIDJournalPublished DateAuthorTitle
21159775J. Biol. Chem.2011Mast N et al.Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1.
20118482J. Biol. Chem.2010Matsushita K et al.Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha.
18450749J. Biol. Chem.2008Bowden K and Ridgway NDOSBP negatively regulates ABCA1 protein stability.