20-hydroxyecdysone

20-hydroxyecdysone is a lipid of Sterol Lipids (ST) class. 20-hydroxyecdysone is associated with abnormalities such as Congenital Abnormality, Obesity, Diabetes, Varicosity and Gilbert Disease. The involved functions are known as Binding (Molecular Function), Anabolism, Embryonic Development, Signal Transduction and Transcriptional Activation. 20-hydroxyecdysone often locates in Epidermis, Epithelium, Body tissue, Head and Blood. The associated genes with 20-hydroxyecdysone are GBGT1 gene, Homologous Gene, Genome, MMRN1 gene and Orthologous Gene. The related lipids are Steroids, muristerone, makisterone, Sterols and Liposomes.

References related to functions published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
7721865	J. Biol. Chem.	1995	Haas AL et al.	Coordinated induction of the ubiquitin conjugation pathway accompanies the developmentally programmed death of insect skeletal muscle.
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15342648	J. Biol. Chem.	2004	Manaka J et al.	Draper-mediated and phosphatidylserine-independent phagocytosis of apoptotic cells by Drosophila hemocytes/macrophages.
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12721294	J. Biol. Chem.	2003	Yamada R and Sonobe H	Purification, kinetic characterization, and molecular cloning of a novel enzyme ecdysteroid-phosphate phosphatase.
12200421	J. Biol. Chem.	2002	Swevers L et al.	The BmE75 nuclear receptors function as dominant repressors of the nuclear receptor BmHR3A.
27551043	J. Biol. Chem.	2016	Wang D et al.	The Steroid Hormone 20-Hydroxyecdysone Promotes the Cytoplasmic Localization of Yorkie to Suppress Cell Proliferation and Induce Apoptosis.
27129227	J. Biol. Chem.	2016	Jing YP et al.	The Steroid Hormone 20-Hydroxyecdysone Enhances Gene Transcription through the cAMP Response Element-binding Protein (CREB) Signaling Pathway.
26272745	J. Biol. Chem.	2015	Dong DJ et al.	The Steroid Hormone 20-Hydroxyecdysone Up-regulates Ste-20 Family Serine/Threonine Kinase Hippo to Induce Programmed Cell Death.
25670853	J. Biol. Chem.	2015	Jing YP et al.	The steroid hormone 20-hydroxyecdysone via nongenomic pathway activates Ca2+/calmodulin-dependent protein kinase II to regulate gene expression.