Tetradecanoic acid

Tetradecanoic acid is a lipid of Fatty Acyls (FA) class. Tetradecanoic acid is associated with abnormalities such as Chronic lung disease, Infection, Spastic syndrome, Diabetes and Cardiovascular Diseases. The involved functions are known as Fatty acid biosynthetic process, Anabolism, lung alveolus development, 5-(carboxyamino)imidazole ribonucleotide mutase activity and Homeostasis. Tetradecanoic acid often locates in Structure of parenchyma of lung, Blood, Head, Membrane and Cytoplasmic matrix. The associated genes with Tetradecanoic acid are SLC33A1 gene, SFTPA1 gene, P4HTM gene, Polypeptides and GPR132 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, palmitoleic acid, Phosphatidylglycerols and Butanols.

References related to functions published in J. Biol. Chem.


PMIDJournalPublished DateAuthorTitle
7822269J. Biol. Chem.1995Wedegaertner PB et al.Lipid modifications of trimeric G proteins.
7836400J. Biol. Chem.1995Franco M et al.Myristoylation of ADP-ribosylation factor 1 facilitates nucleotide exchange at physiological Mg2+ levels.
7782347J. Biol. Chem.1995Randazzo PA et al.The myristoylated amino terminus of ADP-ribosylation factor 1 is a phospholipid- and GTP-sensitive switch.
8636133J. Biol. Chem.1996Vaandrager AB et al.N-terminal myristoylation is required for membrane localization of cGMP-dependent protein kinase type II.
8576155J. Biol. Chem.1996Franco M et al.Myristoylation-facilitated binding of the G protein ARF1GDP to membrane phospholipids is required for its activation by a soluble nucleotide exchange factor.
8576268J. Biol. Chem.1996Morikawa Y et al.Complete inhibition of human immunodeficiency virus Gag myristoylation is necessary for inhibition of particle budding.
8626580J. Biol. Chem.1996Barroso MR et al.A novel Ca2+-binding protein, p22, is required for constitutive membrane traffic.
8824274J. Biol. Chem.1996Steinert PM et al.The transglutaminase 1 enzyme is variably acylated by myristate and palmitate during differentiation in epidermal keratinocytes.
8537345J. Biol. Chem.1995Ames JB et al.Nuclear magnetic resonance evidence for Ca(2+)-induced extrusion of the myristoyl group of recoverin.
7534763J. Biol. Chem.1995Justice JM et al.Involvement of N-myristoylation in monoclonal antibody recognition sites on chimeric G protein alpha subunits.
7536745J. Biol. Chem.1995Wilson PT and Bourne HRFatty acylation of alpha z. Effects of palmitoylation and myristoylation on alpha z signaling.
7499193J. Biol. Chem.1995Lee CM et al.Oligomerization of endothelial nitric oxide synthase. Evidence for a dominant negative effect of truncation mutants.
7642626J. Biol. Chem.1995Joseph M and Nagaraj RConformations of peptides corresponding to fatty acylation sites in proteins. A circular dichroism study.
7629104J. Biol. Chem.1995Justice JM et al.Hydrophobicity and subunit interactions of rod outer segment proteins investigated using Triton X-114 phase partitioning.
9407051J. Biol. Chem.1997Fujii H et al.Nitric oxide inactivates NADPH oxidase in pig neutrophils by inhibiting its assembling process.
9341185J. Biol. Chem.1997Lange A et al.20-Hydroxyeicosatetraenoic acid-induced vasoconstriction and inhibition of potassium current in cerebral vascular smooth muscle is dependent on activation of protein kinase C.
9169413J. Biol. Chem.1997Jinsi-Parimoo A and Deth RCReconstitution of alpha2D-adrenergic receptor coupling to phospholipase D in a PC12 cell lysate.
7530714J. Biol. Chem.1995Robinson LJ et al.Agonist-modulated palmitoylation of endothelial nitric oxide synthase.
7890731J. Biol. Chem.1995Jiang H et al.Ras mediates the activation of phospholipase D by v-Src.
9748261J. Biol. Chem.1998Ashrafi K et al.A role for Saccharomyces cerevisiae fatty acid activation protein 4 in regulating protein N-myristoylation during entry into stationary phase.
10026218J. Biol. Chem.1999Armah DA and Mensa-Wilmot KS-myristoylation of a glycosylphosphatidylinositol-specific phospholipase C in Trypanosoma brucei.
11527981J. Biol. Chem.2001Farazi TA et al.The biology and enzymology of protein N-myristoylation.
11836243J. Biol. Chem.2002O'Callaghan DW et al.Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction.
11312268J. Biol. Chem.2001Ramulu P and Nathans JCellular and subcellular localization, N-terminal acylation, and calcium binding of Caenorhabditis elegans protein phosphatase with EF-hands.
11285262J. Biol. Chem.2001Petitpas I et al.Crystal structure analysis of warfarin binding to human serum albumin: anatomy of drug site I.
11413143J. Biol. Chem.2001Spizz G and Blackshear PJOverexpression of the myristoylated alanine-rich C-kinase substrate inhibits cell adhesion to extracellular matrix components.
12114511J. Biol. Chem.2002Todt JC et al.Activation of protein kinase C beta II by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophages.
12519760J. Biol. Chem.2003Lee DS et al.Substrate recognition and molecular mechanism of fatty acid hydroxylation by cytochrome P450 from Bacillus subtilis. Crystallographic, spectroscopic, and mutational studies.
10601316J. Biol. Chem.1999Wang Y et al.N-Myristoylation and betagamma play roles beyond anchorage in the palmitoylation of the G protein alpha(o) subunit.
10617614J. Biol. Chem.2000Webb Y et al.Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids.
10625681J. Biol. Chem.2000Evanko DS et al.Interaction with Gbetagamma is required for membrane targeting and palmitoylation of Galpha(s) and Galpha(q).
10777537J. Biol. Chem.2000Milne KG and Ferguson MACloning, expression, and characterization of the acyl-CoA-binding protein in African trypanosomes.
10799491J. Biol. Chem.2000Morita YS et al.Glycosyl phosphatidylinositol myristoylation in African trypanosomes. New intermediates in the pathway for fatty acid remodeling.
10766850J. Biol. Chem.2000Paturiaux-Hanocq F et al.A role for the dynamic acylation of a cluster of cysteine residues in regulating the activity of the glycosylphosphatidylinositol-specific phospholipase C of Trypanosoma brucei.
10940303J. Biol. Chem.2000Bhattacharya AA et al.Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures.
10734119J. Biol. Chem.2000Qi Q et al.Molecular cloning, genomic organization, and biochemical characterization of myristoyl-CoA:protein N-myristoyltransferase from Arabidopsis thaliana.
14660555J. Biol. Chem.2004Liang X et al.The N-terminal SH4 region of the Src family kinase Fyn is modified by methylation and heterogeneous fatty acylation: role in membrane targeting, cell adhesion, and spreading.
14707139J. Biol. Chem.2004Ren Y et al.An alternative pathway of oleate beta-oxidation in Escherichia coli involving the hydrolysis of a dead end intermediate by a thioesterase.
14722091J. Biol. Chem.2004Hamasaki-Katagiri N et al.Fission yeast homolog of neuronal calcium sensor-1 (Ncs1p) regulates sporulation and confers calcium tolerance.
21288895J. Biol. Chem.2011Lim S et al.Structure of a Ca2+-myristoyl switch protein that controls activation of a phosphatidylinositol 4-kinase in fission yeast.
20368336J. Biol. Chem.2010Kim G et al.Dual sites of protein initiation control the localization and myristoylation of methionine sulfoxide reductase A.
20177058J. Biol. Chem.2010Hu T et al.Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane.
17416590J. Biol. Chem.2007Isenberg JS et al.Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake.
18077452J. Biol. Chem.2008Koutelou E et al.Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1.
18387941J. Biol. Chem.2008Chambers JW et al.Assembly of heterohexameric trypanosome hexokinases reveals that hexokinase 2 is a regulable enzyme.
15741159J. Biol. Chem.2005Petrescu AD et al.Role of regulatory F-domain in hepatocyte nuclear factor-4alpha ligand specificity.
15970594J. Biol. Chem.2005Zhu W and Smart EJMyristic acid stimulates endothelial nitric-oxide synthase in a CD36- and an AMP kinase-dependent manner.
16556605J. Biol. Chem.2006Sakurai N and Utsumi TPosttranslational N-myristoylation is required for the anti-apoptotic activity of human tGelsolin, the C-terminal caspase cleavage product of human gelsolin.
22170056J. Biol. Chem.2012Top D et al.Cell-cell membrane fusion induced by p15 fusion-associated small transmembrane (FAST) protein requires a novel fusion peptide motif containing a myristoylated polyproline type II helix.
23303187J. Biol. Chem.2013Panjarian S et al.Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors.
23316053J. Biol. Chem.2013Panjarian S et al.Structure and dynamic regulation of Abl kinases.
23530041J. Biol. Chem.2013Russo SB et al.Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties.
22773878J. Biol. Chem.2012Robal T et al.Fatty acids bind tightly to the N-terminal domain of angiopoietin-like protein 4 and modulate its interaction with lipoprotein lipase.
21799007J. Biol. Chem.2011Samal AB et al.NMR, biophysical, and biochemical studies reveal the minimal Calmodulin binding domain of the HIV-1 matrix protein.
20479008J. Biol. Chem.2010Gilio K et al.Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen.
20040600J. Biol. Chem.2010Zimmermann L et al.Direct observation and quantitative analysis of Lck exchange between plasma membrane and cytosol in living T cells.
19906640J. Biol. Chem.2010Nowak DG et al.Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis.
19679652J. Biol. Chem.2009Choi Y et al.N-myristoylated c-Abl tyrosine kinase localizes to the endoplasmic reticulum upon binding to an allosteric inhibitor.
18070877J. Biol. Chem.2008Smith AE et al.PagP activation in the outer membrane triggers R3 core oligosaccharide truncation in the cytoplasm of Escherichia coli O157:H7.
16785235J. Biol. Chem.2006Andriotis VM and Rathjen JPThe Pto kinase of tomato, which regulates plant immunity, is repressed by its myristoylated N terminus.
16051612J. Biol. Chem.2005Lee J et al.PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family.
15010455J. Biol. Chem.2004Fornés A et al.The second intracellular loop of the glycine transporter 2 contains crucial residues for glycine transport and phorbol ester-induced regulation.
12649269J. Biol. Chem.2003Goubaeva F et al.Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides.
12154090J. Biol. Chem.2002Elfering SL et al.Biochemistry of mitochondrial nitric-oxide synthase.
11279221J. Biol. Chem.2001Sweet CR et al.A Chlamydia trachomatis UDP-N-acetylglucosamine acyltransferase selective for myristoyl-acyl carrier protein. Expression in Escherichia coli and formation of hybrid lipid A species.
27129256J. Biol. Chem.2016Tiwari S et al.Silencing of Small Valosin-containing Protein-interacting Protein (SVIP) Reduces Very Low Density Lipoprotein (VLDL) Secretion from Rat Hepatocytes by Disrupting Its Endoplasmic Reticulum (ER)-to-Golgi Trafficking.