Cholic acid

Cholic acid is a lipid of Sterol Lipids (ST) class. Cholic acid is associated with abnormalities such as Cholestasis, Intrahepatic Cholestasis, Atherosclerosis, Diabetes and cholesterol gallstones. The involved functions are known as Homeostasis, Enterohepatic Circulation, Proliferation (morphologic abnormality), Process and Cell Proliferation. Cholic acid often locates in Hepatic, Cytoplasmic matrix, Membrane, Protoplasm and Tissue membrane. The associated genes with Cholic acid are CYP27A1 gene, ABCB11 gene, NR5A2 gene, SLC10A2 gene and SLC10A1 gene. The related lipids are ursocholic acid, Steroids, Cholestenes, Cholestanes and cholanic acid.

References related to functions published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
11606578	J. Biol. Chem.	2001	Sinal CJ et al.	Antagonism of the actions of peroxisome proliferator-activated receptor-alpha by bile acids.
11331284	J. Biol. Chem.	2001	Luo Y et al.	The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor.
10747975	J. Biol. Chem.	2000	del Castillo-Olivares A and Gil G	Alpha 1-fetoprotein transcription factor is required for the expression of sterol 12alpha -hydroxylase, the specific enzyme for cholic acid synthesis. Potential role in the bile acid-mediated regulation of gene transcription.
10998425	J. Biol. Chem.	2000	Urizar NL et al.	The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression.
10867000	J. Biol. Chem.	2000	Hunt MC et al.	The peroxisome proliferator-activated receptor alpha (PPARalpha) regulates bile acid biosynthesis.
11980911	J. Biol. Chem.	2002	Mihalik SJ et al.	Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling.
20233723	J. Biol. Chem.	2010	Schmidt DR et al.	Regulation of bile acid synthesis by fat-soluble vitamins A and D.
21680746	J. Biol. Chem.	2011	Liaset B et al.	Nutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome.
19564333	J. Biol. Chem.	2009	Ivashyna O et al.	Detergent-activated BAX protein is a monomer.
19458090	J. Biol. Chem.	2009	Vankemmelbeke M et al.	Energy-dependent immunity protein release during tol-dependent nuclease colicin translocation.
15047713	J. Biol. Chem.	2004	Yamagata K et al.	Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1.
14766742	J. Biol. Chem.	2004	del Castillo-Olivares A et al.	The role of alpha1-fetoprotein transcription factor/LRH-1 in bile acid biosynthesis: a known nuclear receptor activator that can act as a suppressor of bile acid biosynthesis.
12202481	J. Biol. Chem.	2002	Chen JY et al.	Mice expressing the human CYP7A1 gene in the mouse CYP7A1 knock-out background lack induction of CYP7A1 expression by cholesterol feeding and have increased hypercholesterolemia when fed a high fat diet.