lysophosphatidic acid

lysophosphatidic acid is a lipid of Glycerophospholipids (GP) class. Lysophosphatidic acid is associated with abnormalities such as Atherosclerosis, Alzheimer's Disease, Asthma, Diabetes Mellitus, Non-Insulin-Dependent and Septicemia. The involved functions are known as Inflammation, Chemotaxis, Binding (Molecular Function), Polymerization and Inflammatory Response. Lysophosphatidic acid often locates in Cytoskeleton, Microfilaments, actin cytoskeleton, Extracellular and Structure of germinal center of lymph node. The associated genes with lysophosphatidic acid are TNF gene, MAPK3 gene, RHOA gene, CDC42 gene and ADRBK1 gene. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Lysophosphatidylcholines, Lysophospholipids and Phosphatidic Acid. The related experimental models are Knock-out, Transgenic Model, Rodent Model and Disease model.

References related to functions published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
27405756	J. Biol. Chem.	2016	Tong S et al.	Structural Insight into Substrate Selection and Catalysis of Lipid Phosphate Phosphatase PgpB in the Cell Membrane.
27053111	J. Biol. Chem.	2016	Wakita M et al.	Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells.
26175151	J. Biol. Chem.	2015	Burkhalter RJ et al.	Lysophosphatidic Acid Initiates Epithelial to Mesenchymal Transition and Induces β-Catenin-mediated Transcription in Epithelial Ovarian Carcinoma.
25564613	J. Biol. Chem.	2015	Jacobo SM and Kazlauskas A	Insulin-like growth factor 1 (IGF-1) stabilizes nascent blood vessels.
25542932	J. Biol. Chem.	2014	Ren A et al.	Asymmetrical macromolecular complex formation of lysophosphatidic acid receptor 2 (LPA2) mediates gradient sensing in fibroblasts.
25528375	J. Biol. Chem.	2015	Ohshima N et al.	New members of the mammalian glycerophosphodiester phosphodiesterase family: GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity.
25035428	J. Biol. Chem.	2014	Morales-Lázaro SL et al.	Structural determinants of the transient receptor potential 1 (TRPV1) channel activation by phospholipid analogs.