stearic acid
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
References related to functions published in J. Biol. Chem.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 8798573 | J. Biol. Chem. | 1996 | Reverey H et al. | Differential fatty acid selection during biosynthetic S-acylation of a transmembrane protein (HEF) and other proteins in insect cells (Sf9) and in mammalian cells (CV1). |
| 8940181 | J. Biol. Chem. | 1996 | Kole HK et al. | A synthetic peptide derived from a COOH-terminal domain of the insulin receptor specifically enhances insulin receptor signaling. |
| 9013572 | J. Biol. Chem. | 1997 | Paumen MB et al. | Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. |
| 21697096 | J. Biol. Chem. | 2011 | Xu M et al. | Novel functions of lipid-binding protein 5 in Caenorhabditis elegans fat metabolism. |
| 21257748 | J. Biol. Chem. | 2011 | Calegari VC et al. | Inflammation of the hypothalamus leads to defective pancreatic islet function. |
| 21596756 | J. Biol. Chem. | 2011 | Ting TC et al. | Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells. |
| 17626006 | J. Biol. Chem. | 2007 | Barreyro FJ et al. | Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis. |
| 15851470 | J. Biol. Chem. | 2005 | Scaglia N and Igal RA | Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells. |
| 23306194 | J. Biol. Chem. | 2013 | Lee W et al. | Intracellular Mycobacterium tuberculosis exploits host-derived fatty acids to limit metabolic stress. |
| 20032470 | J. Biol. Chem. | 2010 | Collins JM et al. | De novo lipogenesis and stearoyl-CoA desaturase are coordinately regulated in the human adipocyte and protect against palmitate-induced cell injury. |
| 19734538 | J. Biol. Chem. | 2009 | Masuoka HC et al. | Mcl-1 degradation during hepatocyte lipoapoptosis. |
| 17416903 | J. Biol. Chem. | 2007 | Crunkhorn S et al. | Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. |
| 17127673 | J. Biol. Chem. | 2007 | Sampath H et al. | Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat. |
| 15277519 | J. Biol. Chem. | 2004 | Wong DA et al. | Coordination of peroxisomal beta-oxidation and fatty acid elongation in HepG2 cells. |
| 12105219 | J. Biol. Chem. | 2002 | Liang X et al. | Mass spectrometric analysis of GAP-43/neuromodulin reveals the presence of a variety of fatty acylated species. |
| 11423543 | J. Biol. Chem. | 2001 | Liang X et al. | Heterogeneous fatty acylation of Src family kinases with polyunsaturated fatty acids regulates raft localization and signal transduction. |
| 11085986 | J. Biol. Chem. | 2001 | Hannah VC et al. | Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells. |