Ganglioside GM2

Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.

References related to functions published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
11796728	J. Biol. Chem.	2002	Miljan EA et al.	Interaction of the extracellular domain of the epidermal growth factor receptor with gangliosides.
20430897	J. Biol. Chem.	2010	Vitner EB et al.	Common and uncommon pathogenic cascades in lysosomal storage diseases.
7592631	J. Biol. Chem.	1995	Li SC et al.	Specific recognition of N-acetylneuraminic acid in the GM2 epitope by human GM2 activator protein.
3158659	J. Biol. Chem.	1985	Kytzia HJ and Sandhoff K	Evidence for two different active sites on human beta-hexosaminidase A. Interaction of GM2 activator protein with beta-hexosaminidase A.