Ganglioside GI

Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.

References related to functions published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
15817446	J. Biol. Chem.	2005	Wang TY et al.	Artificially lipid-anchored proteins can elicit clustering-induced intracellular signaling events in Jurkat T-lymphocytes independent of lipid raft association.
26338710	J. Biol. Chem.	2015	Sasaki N et al.	Ganglioside GM1 Contributes to the State of Insulin Resistance in Senescent Human Arterial Endothelial Cells.
24371137	J. Biol. Chem.	2014	Lundius EG et al.	GPR37 protein trafficking to the plasma membrane regulated by prosaposin and GM1 gangliosides promotes cell viability.
23884419	J. Biol. Chem.	2013	Saslowsky DE et al.	Ganglioside GM1-mediated transcytosis of cholera toxin bypasses the retrograde pathway and depends on the structure of the ceramide domain.
22847002	J. Biol. Chem.	2012	Oda M et al.	Clostridium perfringens alpha-toxin recognizes the GM1a-TrkA complex.
22128166	J. Biol. Chem.	2012	Ohto U et al.	Crystal structure of human β-galactosidase: structural basis of Gm1 gangliosidosis and morquio B diseases.
21693704	J. Biol. Chem.	2011	Huang SH et al.	Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3).
17488728	J. Biol. Chem.	2007	Sakai H et al.	ABCA2 deficiency results in abnormal sphingolipid metabolism in mouse brain.
17264085	J. Biol. Chem.	2007	Barfod ET et al.	Ca2+-activated IK1 channels associate with lipid rafts upon cell swelling and mediate volume recovery.
17135262	J. Biol. Chem.	2007	Yamamoto N et al.	A ganglioside-induced toxic soluble Abeta assembly. Its enhanced formation from Abeta bearing the Arctic mutation.
16636068	J. Biol. Chem.	2006	Zhang Q et al.	Metastatic potential of mouse Lewis lung cancer cells is regulated via ganglioside GM1 by modulating the matrix metalloprotease-9 localization in lipid rafts.
15840575	J. Biol. Chem.	2005	Kiyokawa E et al.	Spatial and functional heterogeneity of sphingolipid-rich membrane domains.
15814610	J. Biol. Chem.	2005	Morinaga N et al.	Differential activities of plant polyphenols on the binding and internalization of cholera toxin in vero cells.
15320336	J. Biol. Chem.	2004	Horibata Y et al.	Unique catabolic pathway of glycosphingolipids in a hydrozoan, Hydra magnipapillata, involving endoglycoceramidase.
15247273	J. Biol. Chem.	2004	Triantafilou M et al.	Lipoteichoic acid and toll-like receptor 2 internalization and targeting to the Golgi are lipid raft-dependent.
15215248	J. Biol. Chem.	2004	Liu Y et al.	Exogenous ganglioside GD1a enhances epidermal growth factor receptor binding and dimerization.
15145933	J. Biol. Chem.	2004	Nishio M et al.	Overexpressed GM1 suppresses nerve growth factor (NGF) signals by modulating the intracellular localization of NGF receptors and membrane fluidity in PC12 cells.
14970224	J. Biol. Chem.	2004	Papini N et al.	The plasma membrane-associated sialidase MmNEU3 modifies the ganglioside pattern of adjacent cells supporting its involvement in cell-to-cell interactions.
14707135	J. Biol. Chem.	2004	Ogushi K et al.	Gangliosides act as co-receptors for Salmonella enteritidis FliC and promote FliC induction of human beta-defensin-2 expression in Caco-2 cells.
14613940	J. Biol. Chem.	2004	Tringali C et al.	Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules.
12388556	J. Biol. Chem.	2002	Rabin SJ et al.	Gangliosides activate Trk receptors by inducing the release of neurotrophins.
12237294	J. Biol. Chem.	2002	Crespo PM et al.	Effect of gangliosides on the distribution of a glycosylphosphatidylinositol-anchored protein in plasma membrane from Chinese hamster ovary-K1 cells.
12087095	J. Biol. Chem.	2002	Horstman AL and Kuehn MJ	Bacterial surface association of heat-labile enterotoxin through lipopolysaccharide after secretion via the general secretory pathway.
11877421	J. Biol. Chem.	2002	Lesieur C et al.	A kinetic model of intermediate formation during assembly of cholera toxin B-subunit pentamers.
11782461	J. Biol. Chem.	2002	Mitsuda T et al.	Overexpression of ganglioside GM1 results in the dispersion of platelet-derived growth factor receptor from glycolipid-enriched microdomains and in the suppression of cell growth signals.
11751885	J. Biol. Chem.	2002	Vargas L et al.	Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx.
11479294	J. Biol. Chem.	2001	Rodighiero C et al.	A cholera toxin B-subunit variant that binds ganglioside G(M1) but fails to induce toxicity.
10942779	J. Biol. Chem.	2000	Wilkening G et al.	Degradation of membrane-bound ganglioside GM1. Stimulation by bis(monoacylglycero)phosphate and the activator proteins SAP-B and GM2-AP.
10744673	J. Biol. Chem.	2000	Palestini P et al.	Tubulin anchoring to glycolipid-enriched, detergent-resistant domains of the neuronal plasma membrane.
9556610	J. Biol. Chem.	1998	Kopitz J et al.	Galectin-1 is a major receptor for ganglioside GM1, a product of the growth-controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in culture.
9312075	J. Biol. Chem.	1997	Miyazaki H et al.	Expression cloning of rat cDNA encoding UDP-galactose:GD2 beta1,3-galactosyltransferase that determines the expression of GD1b/GM1/GA1.
7852388	J. Biol. Chem.	1995	Ferrari G et al.	Prevention of apoptotic neuronal death by GM1 ganglioside. Involvement of Trk neurotrophin receptors.
28179425	J. Biol. Chem.	2017	Han YB et al.	Structural Insights into the Broad Substrate Specificity of a Novel Endoglycoceramidase I Belonging to a New Subfamily of GH5 Glycosidases.