Lysophosphatidylcholine

Lysophosphatidylcholine is a lipid of Glycerophospholipids (GP) class. Lysophosphatidylcholine is associated with abnormalities such as Ischemia, Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Fatty Liver and Atherosclerosis. The involved functions are known as Inflammation, antagonists, Signal Transduction, Signal Pathways and Saturated. Lysophosphatidylcholine often locates in Body tissue, Head, integral to membrane, Membrane and Extracellular. The associated genes with Lysophosphatidylcholine are RHOA gene, Homologous Gene, GPR4 gene, GPR68 gene and TRPV2 gene. The related lipids are Nonesterified Fatty Acids, lysophosphatidylethanolamine, Lysophosphatidylcholines, Phosphatidylserines and 25-hydroxycholesterol. The related experimental models are Knock-out and Disease model.

References related to genes published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
11535583	J. Biol. Chem.	2001	Zhu K et al.	Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4.
12885774	J. Biol. Chem.	2003	Duan RD et al.	Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family.
18801741	J. Biol. Chem.	2008	Sato H et al.	Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis.
17726007	J. Biol. Chem.	2007	Jain S et al.	Identification of a novel lysophospholipid acyltransferase in Saccharomyces cerevisiae.
17613534	J. Biol. Chem.	2007	Xie Z et al.	Group VIA phospholipase A2 (iPLA2beta) participates in angiotensin II-induced transcriptional up-regulation of regulator of g-protein signaling-2 in vascular smooth muscle cells.
15927955	J. Biol. Chem.	2005	Ikeno Y et al.	Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor.
12124392	J. Biol. Chem.	2002	Kim YJ et al.	Group V phospholipase A2 induces leukotriene biosynthesis in human neutrophils through the activation of group IVA phospholipase A2.
10196168	J. Biol. Chem.	1999	Martens JS et al.	A modification of apolipoprotein B accounts for most of the induction of macrophage growth by oxidized low density lipoprotein.
9614091	J. Biol. Chem.	1998	Cieslik K et al.	Transcriptional regulation of endothelial nitric-oxide synthase by lysophosphatidylcholine.
9506985	J. Biol. Chem.	1998	Wong JT et al.	Lysophosphatidylcholine stimulates the release of arachidonic acid in human endothelial cells.
9153219	J. Biol. Chem.	1997	Fang X et al.	Lysophosphatidylcholine stimulates activator protein 1 and the c-Jun N-terminal kinase activity.
8910311	J. Biol. Chem.	1996	Sakai M et al.	The scavenger receptor serves as a route for internalization of lysophosphatidylcholine in oxidized low density lipoprotein-induced macrophage proliferation.
8663471	J. Biol. Chem.	1996	Pete MJ and Exton JH	Purification of a lysophospholipase from bovine brain that selectively deacylates arachidonoyl-substituted lysophosphatidylcholine.
7542654	J. Biol. Chem.	1995	Zembowicz A et al.	Transcriptional induction of endothelial nitric oxide synthase type III by lysophosphatidylcholine.