rotenone

rotenone is a lipid of Polyketides (PK) class. Rotenone is associated with abnormalities such as Parkinson Disease, MYOPATHY, DISTAL, WITH ANTERIOR TIBIAL ONSET, Neurodegenerative Disorders, Septicemia and Respiratory Failure. The involved functions are known as Phosphorylation, Process, Cell Death, proteasome activity and Apoptosis. Rotenone often locates in Protoplasm, Presynaptic Terminals, Neurites, NADH dehydrogenase complex and Mitochondria. The associated genes with rotenone are DNAJB9 gene, EIF2S3 gene, Candidate Disease Gene, G-substrate and ERN1 gene. The related lipids are Lipopolysaccharides, Membrane Lipids, Phosphatidylserines, Fatty Acids and Cardiolipins. The related experimental models are Knock-out, Mouse Model, Disease model and Rodent Model.

References related to genes published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
7493931	J. Biol. Chem.	1995	Ebert BL et al.	Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences.
11724769	J. Biol. Chem.	2002	Lee HJ et al.	Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors.
11342529	J. Biol. Chem.	2001	Yamagishi SI et al.	Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A.
11358965	J. Biol. Chem.	2001	Li WG et al.	H(2)O(2)-induced O(2) production by a non-phagocytic NAD(P)H oxidase causes oxidant injury.
12080052	J. Biol. Chem.	2002	Damdimopoulos AE et al.	Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death.
12237311	J. Biol. Chem.	2002	St-Pierre J et al.	Topology of superoxide production from different sites in the mitochondrial electron transport chain.
12952965	J. Biol. Chem.	2003	Grether-Beck S et al.	Mitochondrial cytochrome c release mediates ceramide-induced activator protein 2 activation and gene expression in keratinocytes.
12496265	J. Biol. Chem.	2003	Li N et al.	Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
14561763	J. Biol. Chem.	2004	Uyemura SA et al.	Oxidative phosphorylation and rotenone-insensitive malate- and NADH-quinone oxidoreductases in Plasmodium yoelii yoelii mitochondria in situ.
15317809	J. Biol. Chem.	2004	Muller FL et al.	Complex III releases superoxide to both sides of the inner mitochondrial membrane.
21454572	J. Biol. Chem.	2011	Wen Y et al.	Alternative mitochondrial electron transfer as a novel strategy for neuroprotection.
21536665	J. Biol. Chem.	2011	Than TA et al.	Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells.
21216964	J. Biol. Chem.	2011	Tiwari M et al.	Loss of caspase-2-dependent apoptosis induces autophagy after mitochondrial oxidative stress in primary cultures of young adult cortical neurons.
19033437	J. Biol. Chem.	2009	Gimenez-Cassina A et al.	Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3.
19074146	J. Biol. Chem.	2009	Ren Y et al.	Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating microtubule-associated protein kinase activation.
19019832	J. Biol. Chem.	2009	Tapryal N et al.	Reactive oxygen species regulate ceruloplasmin by a novel mRNA decay mechanism involving its 3'-untranslated region: implications in neurodegenerative diseases.
18940801	J. Biol. Chem.	2008	Dagda RK et al.	The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission.
15234983	J. Biol. Chem.	2004	Zhou Y et al.	Analysis of alpha-synuclein-associated proteins by quantitative proteomics.
17581813	J. Biol. Chem.	2007	Marella M et al.	Mechanism of cell death caused by complex I defects in a rat dopaminergic cell line.
15824110	J. Biol. Chem.	2005	Brown ST et al.	Hypoxic augmentation of Ca2+ channel currents requires a functional electron transport chain.
16410242	J. Biol. Chem.	2006	Schönfeld P and Reiser G	Rotenone-like action of the branched-chain phytanic acid induces oxidative stress in mitochondria.
16243845	J. Biol. Chem.	2005	Panov A et al.	Rotenone model of Parkinson disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication.
16024921	J. Biol. Chem.	2005	Yang T et al.	Hypertonic induction of COX-2 in collecting duct cells by reactive oxygen species of mitochondrial origin.
16091364	J. Biol. Chem.	2005	Ren Y et al.	Selective vulnerability of dopaminergic neurons to microtubule depolymerization.
16085644	J. Biol. Chem.	2005	Shang T et al.	Death-associated protein kinase as a sensor of mitochondrial membrane potential: role of lysosome in mitochondrial toxin-induced cell death.
15849190	J. Biol. Chem.	2005	Pineau B et al.	Targeting the NAD7 subunit to mitochondria restores a functional complex I and a wild type phenotype in the Nicotiana sylvestris CMS II mutant lacking nad7.
16887804	J. Biol. Chem.	2006	Jiang Q et al.	Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons.
18562315	J. Biol. Chem.	2008	Sugeno N et al.	Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death.
25122772	J. Biol. Chem.	2014	Worth AJ et al.	Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation, supporting acetyl-coenzyme A levels.
26416893	J. Biol. Chem.	2015	Won JH et al.	Rotenone-induced Impairment of Mitochondrial Electron Transport Chain Confers a Selective Priming Signal for NLRP3 Inflammasome Activation.
26152715	J. Biol. Chem.	2015	Kelly B et al.	Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages.
25253691	J. Biol. Chem.	2014	Rao DK et al.	A combination of curcumin with either gramicidin or ouabain selectively kills cells that express the multidrug resistance-linked ABCG2 transporter.