quercetin

quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.

References related to genes published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
8567688	J. Biol. Chem.	1996	Boege F et al.	Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I.
8798712	J. Biol. Chem.	1996	McKenna E et al.	Dissociation of phospholamban regulation of cardiac sarcoplasmic reticulum Ca2+ATPase by quercetin.
11834736	J. Biol. Chem.	2002	Song J et al.	Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and Glucose.
12826665	J. Biol. Chem.	2003	Spencer JP et al.	Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability.
12517755	J. Biol. Chem.	2003	Welford RW et al.	The selectivity and inhibition of AlkB.
15292203	J. Biol. Chem.	2004	Spatuzza C et al.	Heat shock induces preferential translation of ERGIC-53 and affects its recycling pathway.
15090535	J. Biol. Chem.	2004	Maggiolini M et al.	The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells.
21705337	J. Biol. Chem.	2011	Volonte D and Galbiati F	Polymerase I and transcript release factor (PTRF)/cavin-1 is a novel regulator of stress-induced premature senescence.
18032389	J. Biol. Chem.	2008	Soundararajan R et al.	Quercetin 3-glucoside protects neuroblastoma (SH-SY5Y) cells in vitro against oxidative damage by inducing sterol regulatory element-binding protein-2-mediated cholesterol biosynthesis.
18199750	J. Biol. Chem.	2008	Kawai Y et al.	Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids.
18378673	J. Biol. Chem.	2008	Cartwright AM et al.	A kinetic analysis of regiospecific glucosylation by two glycosyltransferases of Arabidopsis thaliana: domain swapping to introduce new activities.
16407180	J. Biol. Chem.	2006	Cunningham P et al.	Docking studies show that D-glucose and quercetin slide through the transporter GLUT1.
16407274	J. Biol. Chem.	2006	Terán W et al.	Effector-repressor interactions, binding of a single effector molecule to the operator-bound TtgR homodimer mediates derepression.
15456784	J. Biol. Chem.	2004	Kuo PC et al.	Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells.
17046822	J. Biol. Chem.	2006	Kuo CC et al.	CpG-B oligodeoxynucleotide promotes cell survival via up-regulation of Hsp70 to increase Bcl-xL and to decrease apoptosis-inducing factor translocation.
16982612	J. Biol. Chem.	2006	He XZ et al.	Mutational analysis of the Medicago glycosyltransferase UGT71G1 reveals residues that control regioselectivity for (iso)flavonoid glycosylation.
17135264	J. Biol. Chem.	2007	Ferrer P et al.	Nitric oxide mediates natural polyphenol-induced Bcl-2 down-regulation and activation of cell death in metastatic B16 melanoma.
16162502	J. Biol. Chem.	2005	Marambaud P et al.	Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.
22582396	J. Biol. Chem.	2012	Sekiya M et al.	Binding of phytopolyphenol piceatannol disrupts β/γ subunit interactions and rate-limiting step of steady-state rotational catalysis in Escherichia coli F1-ATPase.
23223575	J. Biol. Chem.	2013	Beazley KE et al.	Quercetin attenuates warfarin-induced vascular calcification in vitro independently from matrix Gla protein.
23396969	J. Biol. Chem.	2013	Corpe CP et al.	Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8.
23902763	J. Biol. Chem.	2013	Kang J et al.	Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines.