rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

References related to genes published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
10383415	J. Biol. Chem.	1999	Reyland ME et al.	Protein kinase C delta is essential for etoposide-induced apoptosis in salivary gland acinar cells.
11744693	J. Biol. Chem.	2002	Han JM et al.	Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells.
11796722	J. Biol. Chem.	2002	Li B et al.	Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C.
11274209	J. Biol. Chem.	2001	Vancurova I et al.	NF-kappa B activation in tumor necrosis factor alpha-stimulated neutrophils is mediated by protein kinase Cdelta. Correlation to nuclear Ikappa Balpha.
12403780	J. Biol. Chem.	2003	Kim HJ et al.	The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2.
12226102	J. Biol. Chem.	2002	Saito S et al.	Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src.
12832423	J. Biol. Chem.	2003	Matthews V et al.	Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE).
12738787	J. Biol. Chem.	2003	Hock MB and Brown MA	Nuclear factor of activated T cells 2 transactivation in mast cells: a novel isoform-specific transactivation domain confers unique FcepsilonRI responsiveness.
12493764	J. Biol. Chem.	2003	Minami T et al.	Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways.
14514687	J. Biol. Chem.	2003	Ham YM et al.	The c-Jun N-terminal kinase 1 activity is differentially regulated by specific mechanisms during apoptosis.
14594813	J. Biol. Chem.	2004	Ryazanova LV et al.	Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel.
21669868	J. Biol. Chem.	2011	López-Huertas MR et al.	Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytes.
20639513	J. Biol. Chem.	2010	Lanaspa MA et al.	The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP.
17307743	J. Biol. Chem.	2007	Lu R et al.	Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells.
15767261	J. Biol. Chem.	2005	Hurbin A et al.	Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells.
16260419	J. Biol. Chem.	2005	Zhao KW et al.	Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK.
17158874	J. Biol. Chem.	2007	Burkhart BA et al.	Osmotic stress-dependent repression is mediated by histone H3 phosphorylation and chromatin structure.