25-Hydroxycholesterol

25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.

References related to genes published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
7642545	J. Biol. Chem.	1995	Payne DW et al.	A novel nonhepatic hydroxycholesterol 7 alpha-hydroxylase that is markedly stimulated by interleukin-1 beta. Characterization in the immature rat ovary.
7744865	J. Biol. Chem.	1995	Yang J et al.	Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution.
9880570	J. Biol. Chem.	1999	Du EZ et al.	Translocation-arrested apolipoprotein B evades proteasome degradation via a sterol-sensitive block in ubiquitin conjugation.
10702300	J. Biol. Chem.	2000	Rusiñol AE et al.	Isolation of a somatic cell mutant resistant to the induction of apoptosis by oxidized low density lipoprotein.
18996837	J. Biol. Chem.	2009	Gale SE et al.	Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions.
18165705	J. Biol. Chem.	2008	Wang PY et al.	The N terminus controls sterol binding while the C terminus regulates the scaffolding function of OSBP.
17142457	J. Biol. Chem.	2007	Hsu MH et al.	Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin.
20406816	J. Biol. Chem.	2010	Hartman IZ et al.	Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets.
19687008	J. Biol. Chem.	2009	Li H et al.	Hepatocyte nuclear factor 1alpha plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine.
18450749	J. Biol. Chem.	2008	Bowden K and Ridgway ND	OSBP negatively regulates ABCA1 protein stability.
15213220	J. Biol. Chem.	2004	Demoulin JB et al.	Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins.
11967256	J. Biol. Chem.	2002	Agellon LB et al.	Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice.