Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

References related to genes published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
20164172	J. Biol. Chem.	2010	Shimada H and Rajagopalan LE	Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acid-mediated expression of cell adhesion molecules via NF-kappaB p65.
8662769	J. Biol. Chem.	1996	Popp B et al.	The role of the N and C termini of recombinant Neurospora mitochondrial porin in channel formation and voltage-dependent gating.
9468503	J. Biol. Chem.	1998	Venkateswarlu K et al.	The N-terminal membrane domain of yeast NADPH-cytochrome P450 (CYP) oxidoreductase is not required for catalytic activity in sterol biosynthesis or in reconstitution of CYP activity.
9092539	J. Biol. Chem.	1997	Kelly SL et al.	Characterization of Saccharomyces cerevisiae CYP61, sterol delta22-desaturase, and inhibition by azole antifungal agents.
10608831	J. Biol. Chem.	1999	Cotrim PC et al.	Isolation of genes mediating resistance to inhibitors of nucleoside and ergosterol metabolism in Leishmania by overexpression/selection.
10973984	J. Biol. Chem.	2000	Cardinale F et al.	Differential activation of four specific MAPK pathways by distinct elicitors.
14645222	J. Biol. Chem.	2004	Branco MR et al.	Decrease of H2O2 plasma membrane permeability during adaptation to H2O2 in Saccharomyces cerevisiae.
15155725	J. Biol. Chem.	2004	Sorger D et al.	A yeast strain lacking lipid particles bears a defect in ergosterol formation.
20959444	J. Biol. Chem.	2010	Porter JR et al.	Ergosterol regulates sterol regulatory element binding protein (SREBP) cleavage in fission yeast.
20647309	J. Biol. Chem.	2010	Klose C et al.	Yeast lipids can phase-separate into micrometer-scale membrane domains.
17954932	J. Biol. Chem.	2007	Craven RJ et al.	Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51.
15817474	J. Biol. Chem.	2005	Gaigg B et al.	Synthesis of sphingolipids with very long chain fatty acids but not ergosterol is required for routing of newly synthesized plasma membrane ATPase to the cell surface of yeast.
24163365	J. Biol. Chem.	2013	Gallo-Ebert C et al.	The yeast anaerobic response element AR1b regulates aerobic antifungal drug-dependent sterol gene expression.