Cholic acid

Cholic acid is a lipid of Sterol Lipids (ST) class. Cholic acid is associated with abnormalities such as Cholestasis, Intrahepatic Cholestasis, Atherosclerosis, Diabetes and cholesterol gallstones. The involved functions are known as Homeostasis, Enterohepatic Circulation, Proliferation (morphologic abnormality), Process and Cell Proliferation. Cholic acid often locates in Hepatic, Cytoplasmic matrix, Membrane, Protoplasm and Tissue membrane. The associated genes with Cholic acid are CYP27A1 gene, ABCB11 gene, NR5A2 gene, SLC10A2 gene and SLC10A1 gene. The related lipids are ursocholic acid, Steroids, Cholestenes, Cholestanes and cholanic acid.

References related to genes published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
8663429	J. Biol. Chem.	1996	Ishibashi S et al.	Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation.
11331284	J. Biol. Chem.	2001	Luo Y et al.	The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor.
10998425	J. Biol. Chem.	2000	Urizar NL et al.	The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression.
10867000	J. Biol. Chem.	2000	Hunt MC et al.	The peroxisome proliferator-activated receptor alpha (PPARalpha) regulates bile acid biosynthesis.
11980911	J. Biol. Chem.	2002	Mihalik SJ et al.	Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling.
14672953	J. Biol. Chem.	2004	Shimamoto Y et al.	Inhibitory effect of the small heterodimer partner on hepatocyte nuclear factor-4 mediates bile acid-induced repression of the human angiotensinogen gene.
17670743	J. Biol. Chem.	2007	Capaldi S et al.	A single amino acid mutation in zebrafish (Danio rerio) liver bile acid-binding protein can change the stoichiometry of ligand binding.
12202481	J. Biol. Chem.	2002	Chen JY et al.	Mice expressing the human CYP7A1 gene in the mouse CYP7A1 knock-out background lack induction of CYP7A1 expression by cholesterol feeding and have increased hypercholesterolemia when fed a high fat diet.