rotenone

rotenone is a lipid of Polyketides (PK) class. Rotenone is associated with abnormalities such as Parkinson Disease, MYOPATHY, DISTAL, WITH ANTERIOR TIBIAL ONSET, Neurodegenerative Disorders, Septicemia and Respiratory Failure. The involved functions are known as Phosphorylation, Process, Cell Death, proteasome activity and Apoptosis. Rotenone often locates in Protoplasm, Presynaptic Terminals, Neurites, NADH dehydrogenase complex and Mitochondria. The associated genes with rotenone are DNAJB9 gene, EIF2S3 gene, Candidate Disease Gene, G-substrate and ERN1 gene. The related lipids are Lipopolysaccharides, Membrane Lipids, Phosphatidylserines, Fatty Acids and Cardiolipins. The related experimental models are Knock-out, Mouse Model, Disease model and Rodent Model.

References related to lipids published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
11342529	J. Biol. Chem.	2001	Yamagishi SI et al.	Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A.
12952965	J. Biol. Chem.	2003	Grether-Beck S et al.	Mitochondrial cytochrome c release mediates ceramide-induced activator protein 2 activation and gene expression in keratinocytes.
15347666	J. Biol. Chem.	2004	Lesnefsky EJ et al.	Blockade of electron transport during ischemia protects cardiac mitochondria.
19019832	J. Biol. Chem.	2009	Tapryal N et al.	Reactive oxygen species regulate ceruloplasmin by a novel mRNA decay mechanism involving its 3'-untranslated region: implications in neurodegenerative diseases.
16410242	J. Biol. Chem.	2006	Schönfeld P and Reiser G	Rotenone-like action of the branched-chain phytanic acid induces oxidative stress in mitochondria.
25122772	J. Biol. Chem.	2014	Worth AJ et al.	Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation, supporting acetyl-coenzyme A levels.