rotenone

rotenone is a lipid of Polyketides (PK) class. Rotenone is associated with abnormalities such as Parkinson Disease, MYOPATHY, DISTAL, WITH ANTERIOR TIBIAL ONSET, Neurodegenerative Disorders, Septicemia and Respiratory Failure. The involved functions are known as Phosphorylation, Process, Cell Death, proteasome activity and Apoptosis. Rotenone often locates in Protoplasm, Presynaptic Terminals, Neurites, NADH dehydrogenase complex and Mitochondria. The associated genes with rotenone are DNAJB9 gene, EIF2S3 gene, Candidate Disease Gene, G-substrate and ERN1 gene. The related lipids are Lipopolysaccharides, Membrane Lipids, Phosphatidylserines, Fatty Acids and Cardiolipins. The related experimental models are Knock-out, Mouse Model, Disease model and Rodent Model.

References related to locations published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
8798503	J. Biol. Chem.	1996	Menz RI and Day DA	Purification and characterization of a 43-kDa rotenone-insensitive NADH dehydrogenase from plant mitochondria.
8663005	J. Biol. Chem.	1996	Rustin P et al.	Fluxes of nicotinamide adenine dinucleotides through mitochondrial membranes in human cultured cells.
9092484	J. Biol. Chem.	1997	Miyako K et al.	The content of intracellular mitochondrial DNA is decreased by 1-methyl-4-phenylpyridinium ion (MPP+).
10347173	J. Biol. Chem.	1999	Barrientos A and Moraes CT	Titrating the effects of mitochondrial complex I impairment in the cell physiology.
11679584	J. Biol. Chem.	2002	Lee HJ et al.	Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form.
11724769	J. Biol. Chem.	2002	Lee HJ et al.	Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors.
11527970	J. Biol. Chem.	2001	Chauvin C et al.	Rotenone inhibits the mitochondrial permeability transition-induced cell death in U937 and KB cells.
12237311	J. Biol. Chem.	2002	St-Pierre J et al.	Topology of superoxide production from different sites in the mitochondrial electron transport chain.
12952965	J. Biol. Chem.	2003	Grether-Beck S et al.	Mitochondrial cytochrome c release mediates ceramide-induced activator protein 2 activation and gene expression in keratinocytes.
12840017	J. Biol. Chem.	2003	Chen Q et al.	Production of reactive oxygen species by mitochondria: central role of complex III.
10969076	J. Biol. Chem.	2000	Lotharius J and O'Malley KL	The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity.
14561763	J. Biol. Chem.	2004	Uyemura SA et al.	Oxidative phosphorylation and rotenone-insensitive malate- and NADH-quinone oxidoreductases in Plasmodium yoelii yoelii mitochondria in situ.
15317809	J. Biol. Chem.	2004	Muller FL et al.	Complex III releases superoxide to both sides of the inner mitochondrial membrane.
15347666	J. Biol. Chem.	2004	Lesnefsky EJ et al.	Blockade of electron transport during ischemia protects cardiac mitochondria.
14963044	J. Biol. Chem.	2004	Batandier C et al.	Opening of the mitochondrial permeability transition pore induces reactive oxygen species production at the level of the respiratory chain complex I.
21454572	J. Biol. Chem.	2011	Wen Y et al.	Alternative mitochondrial electron transfer as a novel strategy for neuroprotection.
21536665	J. Biol. Chem.	2011	Than TA et al.	Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells.
21216964	J. Biol. Chem.	2011	Tiwari M et al.	Loss of caspase-2-dependent apoptosis induces autophagy after mitochondrial oxidative stress in primary cultures of young adult cortical neurons.
19033437	J. Biol. Chem.	2009	Gimenez-Cassina A et al.	Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3.
19019832	J. Biol. Chem.	2009	Tapryal N et al.	Reactive oxygen species regulate ceruloplasmin by a novel mRNA decay mechanism involving its 3'-untranslated region: implications in neurodegenerative diseases.
18940801	J. Biol. Chem.	2008	Dagda RK et al.	The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission.
15234983	J. Biol. Chem.	2004	Zhou Y et al.	Analysis of alpha-synuclein-associated proteins by quantitative proteomics.
17581813	J. Biol. Chem.	2007	Marella M et al.	Mechanism of cell death caused by complex I defects in a rat dopaminergic cell line.
15561720	J. Biol. Chem.	2005	Ahmad IM et al.	Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells.
16410242	J. Biol. Chem.	2006	Schönfeld P and Reiser G	Rotenone-like action of the branched-chain phytanic acid induces oxidative stress in mitochondria.
16243845	J. Biol. Chem.	2005	Panov A et al.	Rotenone model of Parkinson disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication.
15469939	J. Biol. Chem.	2004	Kweon GR et al.	Distinct mechanisms of neurodegeneration induced by chronic complex I inhibition in dopaminergic and non-dopaminergic cells.
16091364	J. Biol. Chem.	2005	Ren Y et al.	Selective vulnerability of dopaminergic neurons to microtubule depolymerization.
16085644	J. Biol. Chem.	2005	Shang T et al.	Death-associated protein kinase as a sensor of mitochondrial membrane potential: role of lysosome in mitochondrial toxin-induced cell death.
15849190	J. Biol. Chem.	2005	Pineau B et al.	Targeting the NAD7 subunit to mitochondria restores a functional complex I and a wild type phenotype in the Nicotiana sylvestris CMS II mutant lacking nad7.
16887804	J. Biol. Chem.	2006	Jiang Q et al.	Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons.
16186119	J. Biol. Chem.	2005	Fujii N et al.	AMP-activated protein kinase alpha2 activity is not essential for contraction- and hyperosmolarity-induced glucose transport in skeletal muscle.
18562315	J. Biol. Chem.	2008	Sugeno N et al.	Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death.
25122772	J. Biol. Chem.	2014	Worth AJ et al.	Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation, supporting acetyl-coenzyme A levels.
26416893	J. Biol. Chem.	2015	Won JH et al.	Rotenone-induced Impairment of Mitochondrial Electron Transport Chain Confers a Selective Priming Signal for NLRP3 Inflammasome Activation.