quercetin

quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.

References related to locations published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
8576124	J. Biol. Chem.	1996	Zhu BT and Liehr JG	Inhibition of catechol O-methyltransferase-catalyzed O-methylation of 2- and 4-hydroxyestradiol by quercetin. Possible role in estradiol-induced tumorigenesis.
8798712	J. Biol. Chem.	1996	McKenna E et al.	Dissociation of phospholamban regulation of cardiac sarcoplasmic reticulum Ca2+ATPase by quercetin.
11500489	J. Biol. Chem.	2001	García-Piñeres AJ et al.	Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones.
11834736	J. Biol. Chem.	2002	Song J et al.	Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and Glucose.
12826665	J. Biol. Chem.	2003	Spencer JP et al.	Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability.
15090535	J. Biol. Chem.	2004	Maggiolini M et al.	The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells.
21705337	J. Biol. Chem.	2011	Volonte D and Galbiati F	Polymerase I and transcript release factor (PTRF)/cavin-1 is a novel regulator of stress-induced premature senescence.
20150427	J. Biol. Chem.	2010	Di Giovanni S et al.	Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity.
18032389	J. Biol. Chem.	2008	Soundararajan R et al.	Quercetin 3-glucoside protects neuroblastoma (SH-SY5Y) cells in vitro against oxidative damage by inducing sterol regulatory element-binding protein-2-mediated cholesterol biosynthesis.
18199750	J. Biol. Chem.	2008	Kawai Y et al.	Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids.
16407180	J. Biol. Chem.	2006	Cunningham P et al.	Docking studies show that D-glucose and quercetin slide through the transporter GLUT1.
15456784	J. Biol. Chem.	2004	Kuo PC et al.	Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells.
17046822	J. Biol. Chem.	2006	Kuo CC et al.	CpG-B oligodeoxynucleotide promotes cell survival via up-regulation of Hsp70 to increase Bcl-xL and to decrease apoptosis-inducing factor translocation.
17135264	J. Biol. Chem.	2007	Ferrer P et al.	Nitric oxide mediates natural polyphenol-induced Bcl-2 down-regulation and activation of cell death in metastatic B16 melanoma.
23223575	J. Biol. Chem.	2013	Beazley KE et al.	Quercetin attenuates warfarin-induced vascular calcification in vitro independently from matrix Gla protein.