LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

References related to locations published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
9139674	J. Biol. Chem.	1997	Carter BZ et al.	Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice.
12783859	J. Biol. Chem.	2003	Yang R et al.	ATP binding to the first nucleotide binding domain of multidrug resistance-associated protein plays a regulatory role at low nucleotide concentration, whereas ATP hydrolysis at the second plays a dominant role in ATP-dependent leukotriene C4 transport.
12882957	J. Biol. Chem.	2003	Payen LF et al.	Role of carboxylate residues adjacent to the conserved core Walker B motifs in the catalytic cycle of multidrug resistance protein 1 (ABCC1).
15355964	J. Biol. Chem.	2004	Zhao Q and Chang XB	Mutation of the aromatic amino acid interacting with adenine moiety of ATP to a polar residue alters the properties of multidrug resistance protein 1.
25371198	J. Biol. Chem.	2014	Bukiya AN et al.	Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4.
26468289	J. Biol. Chem.	2015	Alswied A and Parekh AB	Ca2+ Influx through Store-operated Calcium Channels Replenishes the Functional Phosphatidylinositol 4,5-Bisphosphate Pool Used by Cysteinyl Leukotriene Type I Receptors.