rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
References related to locations published in J. Biol. Chem.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 10383415 | J. Biol. Chem. | 1999 | Reyland ME et al. | Protein kinase C delta is essential for etoposide-induced apoptosis in salivary gland acinar cells. |
| 11274209 | J. Biol. Chem. | 2001 | Vancurova I et al. | NF-kappa B activation in tumor necrosis factor alpha-stimulated neutrophils is mediated by protein kinase Cdelta. Correlation to nuclear Ikappa Balpha. |
| 12832423 | J. Biol. Chem. | 2003 | Matthews V et al. | Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). |
| 12493764 | J. Biol. Chem. | 2003 | Minami T et al. | Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways. |
| 10636851 | J. Biol. Chem. | 2000 | Efimova T and Eckert RL | Regulation of human involucrin promoter activity by novel protein kinase C isoforms. |
| 21669868 | J. Biol. Chem. | 2011 | López-Huertas MR et al. | Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytes. |
| 19648576 | J. Biol. Chem. | 2009 | Esper RM and Loeb JA | Neurotrophins induce neuregulin release through protein kinase Cdelta activation. |
| 20639513 | J. Biol. Chem. | 2010 | Lanaspa MA et al. | The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP. |
| 15998639 | J. Biol. Chem. | 2005 | Zakharov SI et al. | Activation of the BK (SLO1) potassium channel by mallotoxin. |