Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

References related to experimental models published in J. Biol. Chem.

PMID	Journal	Published Date	Author	Title
14732717	J. Biol. Chem.	2004	Sanna MG et al.	Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate.
17283075	J. Biol. Chem.	2007	Jiang LI et al.	Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway.
17284444	J. Biol. Chem.	2007	Kono M et al.	Deafness and stria vascularis defects in S1P2 receptor-null mice.
24003216	J. Biol. Chem.	2013	Herr DR et al.	Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development.
24318881	J. Biol. Chem.	2014	Liu M et al.	Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein.