cholesterol

cholesterol is a lipid of Sterol Lipids (ST) class. Cholesterol is associated with abnormalities such as Trypanosomiasis, Chagas Disease, Cleft Palate, Chondrodysplasia punctata 2, X-linked dominant and Child syndrome. The involved functions are known as Blood Circulation, Sterol Biosynthesis Pathway, Receptor Mediated Endocytosis, Methylation and Signal. Cholesterol often locates in Animal tissue, Blood, Membrane, Plasma membrane and peroxisome. The associated genes with cholesterol are MBD2 gene, SIM, SLC33A1 gene, Genome and NSDHL gene. The related lipids are Sterols, zymosterol, fecosterol, Total cholesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out, Genetically Engineered Mouse and Disease model.

References related to pathways published in J. Biol. Chem.


PMIDJournalPublished DateAuthorTitle
10066752J. Biol. Chem.1999Luker GD et al.Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol.
10329655J. Biol. Chem.1999Bae SH et al.Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue distribution, expression, chromosomal localization, and regulation of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz syndrome-related protein.
10455139J. Biol. Chem.1999Sato R et al.Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription.
10551825J. Biol. Chem.1999Stangl H et al.Transport of lipids from high and low density lipoproteins via scavenger receptor-BI.
10777574J. Biol. Chem.2000Frolov A et al.High density lipoprotein-mediated cholesterol uptake and targeting to lipid droplets in intact L-cell fibroblasts. A single- and multiphoton fluorescence approach.
10809780J. Biol. Chem.2000Yu C et al.Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4.
10918056J. Biol. Chem.2000Liu P et al.Presence of oxidized cholesterol in caveolae uncouples active platelet-derived growth factor receptors from tyrosine kinase substrates.
10964915J. Biol. Chem.2000Millard EE et al.Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis.
11001949J. Biol. Chem.2000Repa JJ et al.Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding.
11279217J. Biol. Chem.2001Kim JH et al.Cholesterol biosynthesis from lanosterol. A concerted role for Sp1 and NF-Y-binding sites for sterol-mediated regulation of rat 7-dehydrocholesterol reductase gene expression.
11323427J. Biol. Chem.2001Miyake JH et al.Increased production of apolipoprotein B-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol 7alpha-hydroxylase.
11504730J. Biol. Chem.2001Fu X et al.27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells.
11577112J. Biol. Chem.2001Janowski BA et al.The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols.
11579092J. Biol. Chem.2001Leventhal AR et al.Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux.
11682487J. Biol. Chem.2002Hao M et al.Vesicular and non-vesicular sterol transport in living cells. The endocytic recycling compartment is a major sterol storage organelle.
12119285J. Biol. Chem.2002Meir K et al.Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis.
12384510J. Biol. Chem.2002Stamatakis K et al.Isoprenylation of RhoB is necessary for its degradation. A novel determinant in the complex regulation of RhoB expression by the mevalonate pathway.
12601003J. Biol. Chem.2003Yu L et al.Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8.
12719428J. Biol. Chem.2003Frolov A et al.NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols.
12736258J. Biol. Chem.2003Williams S et al.X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch.
12847102J. Biol. Chem.2003Kaneko E et al.Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist.
12920113J. Biol. Chem.2003Ohashi K et al.Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene.
12933814J. Biol. Chem.2003Wang L et al.Resistance of SHP-null mice to bile acid-induced liver damage.
14559920J. Biol. Chem.2004Rusiñol AE et al.AKT/protein kinase B regulation of BCL family members during oxysterol-induced apoptosis.
14627708J. Biol. Chem.2004Roitelman J et al.Apomine, a novel hypocholesterolemic agent, accelerates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and stimulates low density lipoprotein receptor activity.
14734557J. Biol. Chem.2004Hao M et al.Effects of cholesterol depletion and increased lipid unsaturation on the properties of endocytic membranes.
15096493J. Biol. Chem.2004Pulfer MK and Murphy RCFormation of biologically active oxysterols during ozonolysis of cholesterol present in lung surfactant.
15173162J. Biol. Chem.2004Davis HR et al.Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis.
15317807J. Biol. Chem.2004Du X et al.Effects of 25-hydroxycholesterol on cholesterol esterification and sterol regulatory element-binding protein processing are dissociable: implications for cholesterol movement to the regulatory pool in the endoplasmic reticulum.
15611112J. Biol. Chem.2005Yu L et al.Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion.
15750181J. Biol. Chem.2005Yu C et al.Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase (JNK) by activated hepatocyte fibroblast growth factor receptor 4 (FGFR4) and bile acids.
15866869J. Biol. Chem.2005Lee PC et al.Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.
16249181J. Biol. Chem.2006Vainio S et al.Significance of sterol structural specificity. Desmosterol cannot replace cholesterol in lipid rafts.
16282330J. Biol. Chem.2006Datta S et al.Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter by nuclear receptors liver receptor homologue-1 and small heterodimer partner: a mechanism for differential regulation of cholesterol synthesis and uptake.
16524875J. Biol. Chem.2006Abildayeva K et al.24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux.
16547009J. Biol. Chem.2006Jean-Louis S et al.Deoxycholic acid induces intracellular signaling through membrane perturbations.
16606610J. Biol. Chem.2006Yamamoto Y et al.Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity.
16735517J. Biol. Chem.2006Megha O et al.Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders.
16737966J. Biol. Chem.2006Sugii S et al.Roles of endogenously synthesized sterols in the endocytic pathway.
16857673J. Biol. Chem.2006Yang C et al.Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands.
17186944J. Biol. Chem.2007Beyea MM et al.Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol.
17573352J. Biol. Chem.2007Xu S et al.Structural basis of sterol binding by NPC2, a lysosomal protein deficient in Niemann-Pick type C2 disease.
17635920J. Biol. Chem.2007Nguyen AD et al.Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs.
17652086J. Biol. Chem.2007Pertusa M et al.Transcriptional control of cholesterol biosynthesis in Schwann cells by axonal neuregulin 1.
17981807J. Biol. Chem.2008Wong J et al.Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis.
18024962J. Biol. Chem.2008Lange Y et al.Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase.
19029290J. Biol. Chem.2009Liu R et al.Characterization of fluorescent sterol binding to purified human NPC1.
19351882J. Biol. Chem.2009Royer MC et al.7-ketocholesterol incorporation into sphingolipid/cholesterol-enriched (lipid raft) domains is impaired by vitamin E: a specific role for alpha-tocopherol with consequences on cell death.
19846551J. Biol. Chem.2009Capyk JK et al.Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids.
19910460J. Biol. Chem.2010Seronello S et al.Ethanol enhances hepatitis C virus replication through lipid metabolism and elevated NADH/NAD+.
20843794J. Biol. Chem.2010Johnston JB et al.Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.
21186286J. Biol. Chem.2011Cheong MC et al.A potential biochemical mechanism underlying the influence of sterol deprivation stress on Caenorhabditis elegans longevity.
21632547J. Biol. Chem.2011Yoshiyama-Yanagawa T et al.The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme.
21813643J. Biol. Chem.2011Shinkyo R et al.Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate.
21987574J. Biol. Chem.2011Capyk JK et al.Activity of 3-ketosteroid 9α-hydroxylase (KshAB) indicates cholesterol side chain and ring degradation occur simultaneously in Mycobacterium tuberculosis.
8662919J. Biol. Chem.1996Berkhout TA et al.The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
8663152J. Biol. Chem.1996Frolov A et al.Spontaneous and protein-mediated sterol transfer between intracellular membranes.
8663430J. Biol. Chem.1996Schwarz M et al.Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase.
8702514J. Biol. Chem.1996Spady DK et al.Feedback regulation of hepatic 7alpha-hydroxylase expression by bile salts in the hamster.
9013544J. Biol. Chem.1997Lehmann JM et al.Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway.
9202016J. Biol. Chem.1997Lange Y et al.The fate of cholesterol exiting lysosomes.
9228075J. Biol. Chem.1997Paton VG et al.Cloning and subcellular localization of hamster and rat isopentenyl diphosphate dimethylallyl diphosphate isomerase. A PTS1 motif targets the enzyme to peroxisomes.
9374499J. Biol. Chem.1997Björkhem I et al.Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro.
9497372J. Biol. Chem.1998Brand C et al.Transforming growth factor beta1 decreases cholesterol supply to mitochondria via repression of steroidogenic acute regulatory protein expression.
9632664J. Biol. Chem.1998Rosenfeld JM and Osborne TFHLH106, a Drosophila sterol regulatory element-binding protein in a natural cholesterol auxotroph.
9632696J. Biol. Chem.1998Arakane F et al.The mechanism of action of steroidogenic acute regulatory protein (StAR). StAR acts on the outside of mitochondria to stimulate steroidogenesis.
9660774J. Biol. Chem.1998Pikuleva IA et al.Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways.
9748295J. Biol. Chem.1998Pai JT et al.Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins.
9804848J. Biol. Chem.1998Christenson LK et al.Oxysterol regulation of steroidogenic acute regulatory protein gene expression. Structural specificity and transcriptional and posttranscriptional actions.
9915865J. Biol. Chem.1999Visconti PE et al.Cholesterol efflux-mediated signal transduction in mammalian sperm. beta-cyclodextrins initiate transmembrane signaling leading to an increase in protein tyrosine phosphorylation and capacitation.