rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
References related to genes published in J. Immunol.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 11313407 | J. Immunol. | 2001 | Solomou EE et al. | Protein kinase C-theta participates in the activation of cyclic AMP-responsive element-binding protein and its subsequent binding to the -180 site of the IL-2 promoter in normal human T lymphocytes. |
| 12421956 | J. Immunol. | 2002 | Cipriani B et al. | Involvement of classical and novel protein kinase C isoforms in the response of human V gamma 9V delta 2 T cells to phosphate antigens. |
| 12817007 | J. Immunol. | 2003 | Deb DK et al. | Activation of protein kinase C delta by IFN-gamma. |
| 17404251 | J. Immunol. | 2007 | Guo B et al. | Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn. |
| 15494525 | J. Immunol. | 2004 | Bey EA et al. | Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes. |
| 16982890 | J. Immunol. | 2006 | Sarkis PT et al. | STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-alpha. |