rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
References related to functions published in J. Leukoc. Biol.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 11994512 | J. Leukoc. Biol. | 2002 | Hendey B et al. | Fas activation opposes PMA-stimulated changes in the localization of PKCdelta: a mechanism for reducing neutrophil adhesion to endothelial cells. |
| 21393419 | J. Leukoc. Biol. | 2011 | Uruno A et al. | All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta. |
| 17077164 | J. Leukoc. Biol. | 2007 | Grybko MJ et al. | Protein kinase C activity is required for cytotoxic T cell lytic granule exocytosis, but the theta isoform does not play a preferential role. |
| 16614259 | J. Leukoc. Biol. | 2006 | Cronshaw DG et al. | Evidence that phospholipase-C-dependent, calcium-independent mechanisms are required for directional migration of T-lymphocytes in response to the CCR4 ligands CCL17 and CCL22. |
| 18511573 | J. Leukoc. Biol. | 2008 | Lee MC et al. | Novel PKC signaling is required for LPS-induced soluble Flt-1 expression in macrophages. |