Lysophosphatidylcholine
Lysophosphatidylcholine is a lipid of Glycerophospholipids (GP) class. Lysophosphatidylcholine is associated with abnormalities such as Ischemia, Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Fatty Liver and Atherosclerosis. The involved functions are known as Inflammation, antagonists, Signal Transduction, Signal Pathways and Saturated. Lysophosphatidylcholine often locates in Body tissue, Head, integral to membrane, Membrane and Extracellular. The associated genes with Lysophosphatidylcholine are RHOA gene, Homologous Gene, GPR4 gene, GPR68 gene and TRPV2 gene. The related lipids are Nonesterified Fatty Acids, lysophosphatidylethanolamine, Lysophosphatidylcholines, Phosphatidylserines and 25-hydroxycholesterol. The related experimental models are Knock-out and Disease model.
References related to abnormalities published in J. Lipid Res.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 25510248 | J. Lipid Res. | 2015 | Takahashi H et al. | Metabolomics reveal 1-palmitoyl lysophosphatidylcholine production by peroxisome proliferator-activated receptor α. |
| 26839333 | J. Lipid Res. | 2016 | Fernandez-Ruiz I et al. | Differential lipid metabolism in monocytes and macrophages: influence of cholesterol loading. |
| 25646365 | J. Lipid Res. | 2015 | Navab M et al. | Source and role of intestinally derived lysophosphatidic acid in dyslipidemia and atherosclerosis. |
| 21908646 | J. Lipid Res. | 2011 | Hollie NI and Hui DY | Group 1B phospholipase A₂ deficiency protects against diet-induced hyperlipidemia in mice. |
| 21447485 | J. Lipid Res. | 2011 | Han MS et al. | Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance. |
| 19458387 | J. Lipid Res. | 2009 | Testerink N et al. | Depletion of phosphatidylcholine affects endoplasmic reticulum morphology and protein traffic at the Golgi complex. |
| 17951222 | J. Lipid Res. | 2008 | Han MS et al. | Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes. |
| 12562829 | J. Lipid Res. | 2003 | Drobnik W et al. | Plasma ceramide and lysophosphatidylcholine inversely correlate with mortality in sepsis patients. |
| 11861673 | J. Lipid Res. | 2002 | Tokumura A et al. | Increased formation of lysophosphatidic acids by lysophospholipase D in serum of hypercholesterolemic rabbits. |
| 10508201 | J. Lipid Res. | 1999 | Golfman LS et al. | Lysophosphatidylcholine induces arachidonic acid release and calcium overload in cardiac myoblastic H9c2 cells. |
| 10357830 | J. Lipid Res. | 1999 | Gómez-Muñoz A et al. | Lysophosphatidylcholine stimulates phospholipase D activity in mouse peritoneal macrophages. |