sphingosylphosphorylcholine

sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.

References related to abnormalities published in J. Lipid Res.


PMIDJournalPublished DateAuthorTitle
23509404J. Lipid Res.2013Morris AJ and Smyth SSLysophosphatidic acid and cardiovascular disease: seeing is believing.
11590211J. Lipid Res.2001Higuchi K et al.Sphingosylphosphorylcholine is an activator of transglutaminase activity in human keratinocytes.
12518027J. Lipid Res.2003Okamoto R et al.Sphingosylphosphorylcholine is upregulated in the stratum corneum of patients with atopic dermatitis.
17592175J. Lipid Res.2007Xin C et al.Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation.