25-Hydroxycholesterol

25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.

References related to abnormalities published in J. Lipid Res.


PMIDJournalPublished DateAuthorTitle
11792719J. Lipid Res.2002Hayden JM et al.Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol.
19502589J. Lipid Res.2009Diczfalusy U et al.Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide.
19812052J. Lipid Res.2010Schüle R et al.Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.