cholesterol is a lipid of Sterol Lipids (ST) class. Cholesterol is associated with abnormalities such as Trypanosomiasis, Chagas Disease, Cleft Palate, Chondrodysplasia punctata 2, X-linked dominant and Child syndrome. The involved functions are known as Blood Circulation, Sterol Biosynthesis Pathway, Receptor Mediated Endocytosis, Methylation and Signal. Cholesterol often locates in Animal tissue, Blood, Membrane, Plasma membrane and peroxisome. The associated genes with cholesterol are MBD2 gene, SIM, SLC33A1 gene, Genome and NSDHL gene. The related lipids are Sterols, zymosterol, fecosterol, Total cholesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out, Genetically Engineered Mouse and Disease model.

References related to functions published in J. Lipid Res.

PMIDJournalPublished DateAuthorTitle
9469584J. Lipid Res.1998Honda A et al.Down-regulation of cholesterol biosynthesis in sitosterolemia: diminished activities of acetoacetyl-CoA thiolase, 3-hydroxy-3-methylglutaryl-CoA synthase, reductase, squalene synthase, and 7-dehydrocholesterol delta7-reductase in liver and mononuclear leukocytes.
9548596J. Lipid Res.1998Honda M et al.7-Dehydrocholesterol down-regulates cholesterol biosynthesis in cultured Smith-Lemli-Opitz syndrome skin fibroblasts.
9507994J. Lipid Res.1998Field FJ et al.Transport of cholesterol from the endoplasmic reticulum to the plasma membrane is constitutive in CaCo-2 cells and differs from the transport of plasma membrane cholesterol to the endoplasmic reticulum.
9555952J. Lipid Res.1998Howell TJ et al.Phytosterols partially explain differences in cholesterol metabolism caused by corn or olive oil feeding.
9555953J. Lipid Res.1998Halvorsen B et al.Effect of a coffee lipid (cafestol) on cholesterol metabolism in human skin fibroblasts.
9869656J. Lipid Res.1999Lagace TA et al.Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol.
9869658J. Lipid Res.1999Sandhoff R et al.Determination of cholesterol at the low picomole level by nano-electrospray ionization tandem mass spectrometry.
9788246J. Lipid Res.1998Vine DF et al.Dietary oxysterols are incorporated in plasma triglyceride-rich lipoproteins, increase their susceptibility to oxidation and increase aortic cholesterol concentration of rabbits.
9741696J. Lipid Res.1998Schwarz M et al.Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia.
10393213J. Lipid Res.1999Gauthier B et al.Characterization of a cholesterol response element (CRE) in the promoter of the cholesteryl ester transfer protein gene: functional role of the transcription factors SREBP-1a, -2, and YY1.
10357847J. Lipid Res.1999Batta AK et al.Highly simplified method for gas-liquid chromatographic quantitation of bile acids and sterols in human stool.
9717719J. Lipid Res.1998Björkhem I et al.Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation.
9717721J. Lipid Res.1998Xu G et al.Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: effects of cholesterol feeding and bile acid depletion.
10064734J. Lipid Res.1999Gaoua W et al.Oxidized derivatives of 7-dehydrocholesterol induce growth retardation in cultured rat embryos: a model for antenatal growth retardation in the Smith-Lemli-Opitz syndrome.
10064742J. Lipid Res.1999Amigo L et al.Enrichment of canalicular membrane with cholesterol and sphingomyelin prevents bile salt-induced hepatic damage.
10191283J. Lipid Res.1999Gylling H et al.Serum sterols during stanol ester feeding in a mildly hypercholesterolemic population.
10191297J. Lipid Res.1999Boehler N et al.Antilithiasic effect of beta-cyclodextrin in LPN hamster: comparison with cholestyramine.
10508204J. Lipid Res.1999Lyons MA et al.Rapid hepatic metabolism of 7-ketocholesterol in vivo: implications for dietary oxysterols.
10553006J. Lipid Res.1999Eckhardt ER et al.Asymmetric distribution of phosphatidylcholine and sphingomyelin between micellar and vesicular phases. Potential implications for canalicular bile formation.
10428977J. Lipid Res.1999Babiker A et al.Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmonary origin.
10428985J. Lipid Res.1999Wrenn SP et al.A fluorescence energy transfer study of lecithin-cholesterol vesicles in the presence of phospholipase C.
9831637J. Lipid Res.1998Del Puppo M et al.Serum 27-hydroxycholesterol in patients with primary biliary cirrhosis suggests alteration of cholesterol catabolism to bile acids via the acidic pathway.
11254756J. Lipid Res.2001Del Puppo M et al.Cholesterol metabolism in primary biliary cirrhosis during simvastatin and UDCA administration.
11160367J. Lipid Res.2001Meaney S et al.Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study.
11590214J. Lipid Res.2001Nanjee MN et al.Intravenous apoA-I/lecithin discs increase pre-beta-HDL concentration in tissue fluid and stimulate reverse cholesterol transport in humans.
11590226J. Lipid Res.2001Field FJ et al.Regulation of sterol regulatory element-binding proteins by cholesterol flux in CaCo-2 cells.
11590227J. Lipid Res.2001Johnson DW et al.A rapid screening procedure for cholesterol and dehydrocholesterol by electrospray ionization tandem mass spectrometry.
11483626J. Lipid Res.2001Sehayek E et al.Hyodeoxycholic acid efficiently suppresses atherosclerosis formation and plasma cholesterol levels in mice.
11483629J. Lipid Res.2001Moschetta A et al.Cholesterol crystallization in model biles: effects of bile salt and phospholipid species composition.
11907135J. Lipid Res.2002Davis RA et al.Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHP.
11907143J. Lipid Res.2002Portincasa P et al.Quantitation of cholesterol crystallization from supersaturated model bile.
11290837J. Lipid Res.2001Zhang Z et al.Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations.
11369800J. Lipid Res.2001Wrenn SP et al.Characterization of model bile using fluorescence energy transfer from dehydroergosterol to dansylated lecithin.
11441136J. Lipid Res.2001Lindenthal B et al.Neutral sterols of rat epididymis. High concentrations of dehydrocholesterols in rat caput epididymidis.
12091488J. Lipid Res.2002Moschetta A et al.Incorporation of cholesterol in sphingomyelin- phosphatidylcholine vesicles has profound effects on detergent-induced phase transitions.
12091491J. Lipid Res.2002Lindenthal B et al.Serum plant sterols and biliary cholesterol secretion in humans: studies with ursodeoxycholic acid.
12364550J. Lipid Res.2002Pappu AS et al.Feedback inhibition of the cholesterol biosynthetic pathway in patients with Smith-Lemli-Opitz syndrome as demonstrated by urinary mevalonate excretion.
12401895J. Lipid Res.2002Wang DQ and Tazuma SEffect of beta-muricholic acid on the prevention and dissolution of cholesterol gallstones in C57L/J mice.
12700338J. Lipid Res.2003Prinsen BH et al.Endogenous cholesterol synthesis is associated with VLDL-2 apoB-100 production in healthy humans.
12562824J. Lipid Res.2003Igel M et al.Comparison of the intestinal uptake of cholesterol, plant sterols, and stanols in mice.
12562840J. Lipid Res.2003Matthan NR et al.Impact of simvastatin, niacin, and/or antioxidants on cholesterol metabolism in CAD patients with low HDL.
12562864J. Lipid Res.2003Staprans I et al.Oxidized cholesterol in the diet is a source of oxidized lipoproteins in human serum.
12588946J. Lipid Res.2003Wang DQ and Carey MCMeasurement of intestinal cholesterol absorption by plasma and fecal dual-isotope ratio, mass balance, and lymph fistula methods in the mouse: an analysis of direct versus indirect methodologies.
12518023J. Lipid Res.2003Canuto RA et al.Apoptosis induced by clofibrate in Yoshida AH-130 hepatoma cells: role of HMG-CoA reductase.
10588952J. Lipid Res.1999Lange Y et al.Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol.
10744778J. Lipid Res.2000Mouzeyan A et al.A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2.
10744785J. Lipid Res.2000Gaoua W et al.Cholesterol deficit but not accumulation of aberrant sterols is the major cause of the teratogenic activity in the Smith-Lemli-Opitz syndrome animal model.
11060346J. Lipid Res.2000Ruan B et al.Aberrant pathways in the late stages of cholesterol biosynthesis in the rat. Origin and metabolic fate of unsaturated sterols relevant to the Smith-Lemli-Opitz syndrome.
11060358J. Lipid Res.2000Salen G et al.Hyperabsorption and retention of campestanol in a sitosterolemic homozygote: comparison with her mother and three control subjects.
11013305J. Lipid Res.2000Norlin M et al.24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A).
10946005J. Lipid Res.2000Colles SM and Chisolm GMLysophosphatidylcholine-induced cellular injury in cultured fibroblasts involves oxidative events.
10946022J. Lipid Res.2000Jira PE et al.Simvastatin. A new therapeutic approach for Smith-Lemli-Opitz syndrome.
10946023J. Lipid Res.2000Spitsen GM et al.In nonhepatic cells, cholesterol 7alpha-hydroxylase induces the expression of genes regulating cholesterol biosynthesis, efflux, and homeostasis.
10706592J. Lipid Res.2000Honda A et al.Regulation of 25- and 27-hydroxylation side chain cleavage pathways for cholic acid biosynthesis in humans, rabbits, and mice. Assay of enzyme activities by high-resolution gas chromatography;-mass spectrometry.
10681402J. Lipid Res.2000Lütjohann D et al.Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients.
10681406J. Lipid Res.2000Brown AJ et al.Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells. Accumulation of oxidized esters in lysosomes.
12177163J. Lipid Res.2002Chevy F et al.Limb malformations of rat fetuses exposed to a distal inhibitor of cholesterol biosynthesis.
11181748J. Lipid Res.2001Nguyen LB et al.Mechanisms for cholesterol homeostasis in rat jejunal mucosa: effects of cholesterol, sitosterol, and lovastatin.
15314096J. Lipid Res.2004Serbanescu I et al.Lovastatin exacerbates atypical absence seizures with only minimal effects on brain sterols.
15314097J. Lipid Res.2004Merris M et al.Long-term effects of sterol depletion in C. elegans: sterol content of synchronized wild-type and mutant populations.
15258193J. Lipid Res.2004Keller RK et al.Enzyme blockade: a nonradioactive method to determine the absolute rate of cholesterol synthesis in the brain.
15102882J. Lipid Res.2004Duan LP et al.Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice.
15145983J. Lipid Res.2004Schwartz CC et al.Lipoprotein cholesteryl ester production, transfer, and output in vivo in humans.
21576600J. Lipid Res.2011Schwend T et al.Requirement of Npc1 and availability of cholesterol for early embryonic cell movements in zebrafish.
21335323J. Lipid Res.2011Ollero M et al.Plasma lipidomics reveals potential prognostic signatures within a cohort of cystic fibrosis patients.
21335619J. Lipid Res.2011Shafaati M et al.Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation.
21382968J. Lipid Res.2011Wewer V et al.Quantification of sterol lipids in plants by quadrupole time-of-flight mass spectrometry.
20921334J. Lipid Res.2011Tomono S et al.Formation of cholesterol ozonolysis products in vitro and in vivo through a myeloperoxidase-dependent pathway.
19224871J. Lipid Res.2009Hynynen R et al.OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids.
19202195J. Lipid Res.2009Nagao K et al.Sodium taurocholate-dependent lipid efflux by ABCA1: effects of W590S mutation on lipid translocation and apolipoprotein A-I dissociation.
19043140J. Lipid Res.2009van Himbergen TM et al.Comparison of the effects of maximal dose atorvastatin and rosuvastatin therapy on cholesterol synthesis and absorption markers.
19141868J. Lipid Res.2009Temel RE et al.Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent.
19502590J. Lipid Res.2009Paillasse MR et al.Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion.
19474457J. Lipid Res.2010Shafaati M et al.The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo.
19578163J. Lipid Res.2010Matthan NR et al.Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial.
19401598J. Lipid Res.2009Lange Y et al.Regulation of fibroblast mitochondrial 27-hydroxycholesterol production by active plasma membrane cholesterol.
19436064J. Lipid Res.2009Matthan NR et al.Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD.
20228406J. Lipid Res.2010Silbernagel G et al.The associations of cholesterol metabolism and plasma plant sterols with all-cause and cardiovascular mortality.
19828909J. Lipid Res.2010Jakulj L et al.Baseline cholesterol absorption and the response to ezetimibe/simvastatin therapy: a post-hoc analysis of the ENHANCE trial.
20656919J. Lipid Res.2010Kriska T et al.Sterol carrier protein-2 (SCP-2) involvement in cholesterol hydroperoxide cytotoxicity as revealed by SCP-2 inhibitor effects.
20567027J. Lipid Res.2010Rodríguez IR and Larrayoz IMCholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration.
20147702J. Lipid Res.2010Staneva G et al.Comparison of the liquid-ordered bilayer phases containing cholesterol or 7-dehydrocholesterol in modeling Smith-Lemli-Opitz syndrome.
19965586J. Lipid Res.2010Charman M et al.MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 protein.
20037138J. Lipid Res.2010Zhu J et al.Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake.
21817059J. Lipid Res.2011Xu L et al.Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome.
22285872J. Lipid Res.2012Paillasse MR et al.Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles.
17251593J. Lipid Res.2007Karu K et al.Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols.
17699733J. Lipid Res.2007Gregor MF and Hotamisligil GSThematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease.
17726195J. Lipid Res.2007Valasek MA et al.Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse.
15576852J. Lipid Res.2005Leoni V et al.Levels of 7-oxocholesterol in cerebrospinal fluid are more than one thousand times lower than reported in multiple sclerosis.
15604516J. Lipid Res.2005Harwood HJ et al.Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase.
16264196J. Lipid Res.2006Wang J et al.Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice.
15466366J. Lipid Res.2004Meaney S et al.Serum cholestenoic acid as a potential marker of pulmonary cholesterol homeostasis: increased levels in patients with pulmonary alveolar proteinosis.
15489546J. Lipid Res.2005Lembcke J et al.Rapid quantification of free and esterified phytosterols in human serum using APPI-LC-MS/MS.
15520451J. Lipid Res.2005Plat J et al.Common sequence variations in ABCG8 are related to plant sterol metabolism in healthy volunteers.
15897605J. Lipid Res.2005Rodriguez-Agudo D et al.Human StarD5, a cytosolic StAR-related lipid binding protein.
15930515J. Lipid Res.2005Yu L et al.Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8.
15930518J. Lipid Res.2005Hayashi M et al.Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7.
17074925J. Lipid Res.2007Pinedo S et al.Plasma levels of plant sterols and the risk of coronary artery disease: the prospective EPIC-Norfolk Population Study.
17012751J. Lipid Res.2007Bhattacharyya AK et al.Cholestanol metabolism in patients with cerebrotendinous xanthomatosis: absorption, turnover, and tissue deposition.
16983147J. Lipid Res.2006Pappu AS et al.Increased nonsterol isoprenoids, dolichol and ubiquinone, in the Smith-Lemli-Opitz syndrome: effects of dietary cholesterol.
17088262J. Lipid Res.2007Li T et al.PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine.
17127773J. Lipid Res.2007Zhou W et al.Cholesterol import fails to prevent catalyst-based inhibition of ergosterol synthesis and cell proliferation of Trypanosoma brucei.
16741293J. Lipid Res.2006Kosters A et al.The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice.
18769018J. Lipid Res.2009Silbernagel G et al.The relationships of cholesterol metabolism and plasma plant sterols with the severity of coronary artery disease.
22279184J. Lipid Res.2012Vanmierlo T et al.Dietary intake of plant sterols stably increases plant sterol levels in the murine brain.
22203775J. Lipid Res.2012Sato Y et al.Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology.
22891291J. Lipid Res.2012Meljon A et al.Analysis of bioactive oxysterols in newborn mouse brain by LC/MS.
23431047J. Lipid Res.2013Gardès C et al.Differential regulation of bile acid and cholesterol metabolism by the farnesoid X receptor in Ldlr -/- mice versus hamsters.
23284090J. Lipid Res.2013Ali Z et al.On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice.
23178226J. Lipid Res.2013Jakulj L et al.Plasma plant sterols serve as poor markers of cholesterol absorption in man.
23999864J. Lipid Res.2013Fan J et al.Hormonal modulators of glial ABCA1 and apoE levels.