25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
References related to functions published in J. Lipid Res.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 24085744 | J. Lipid Res. | 2013 | Navab M et al. | Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid. |
| 11590225 | J. Lipid Res. | 2001 | Panini SR et al. | Arachidonate metabolism and the signaling pathway of induction of apoptosis by oxidized LDL/oxysterol. |
| 11792719 | J. Lipid Res. | 2002 | Hayden JM et al. | Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol. |
| 21652732 | J. Lipid Res. | 2011 | Diczfalusy U and Björkhem I | Still another activity by the highly promiscuous enzyme CYP3A4: 25-hydroxylation of cholesterol. |
| 19229075 | J. Lipid Res. | 2009 | Lu R et al. | FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. |
| 19502589 | J. Lipid Res. | 2009 | Diczfalusy U et al. | Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide. |
| 19617589 | J. Lipid Res. | 2010 | Lee PC and DeBose-Boyd RA | Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells. |
| 19812052 | J. Lipid Res. | 2010 | Schüle R et al. | Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. |
| 17890683 | J. Lipid Res. | 2007 | Li X et al. | Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta,25-diol 3-sulfate, in hepatocytes. |
| 17586788 | J. Lipid Res. | 2007 | Lee PC et al. | Amplification of the gene for SCAP, coupled with Insig-1 deficiency, confers sterol resistance in mutant Chinese hamster ovary cells. |
| 17452746 | J. Lipid Res. | 2007 | Kallin A et al. | SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma. |
| 12454275 | J. Lipid Res. | 2002 | Meaney S et al. | On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function. |
| 27530118 | J. Lipid Res. | 2016 | Li J et al. | Oxysterol binding protein-related protein 8 mediates the cytotoxicity of 25-hydroxycholesterol. |
| 26497473 | J. Lipid Res. | 2015 | Iaea DB et al. | A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol. |
| 24891333 | J. Lipid Res. | 2014 | Sekiya M et al. | Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages. |