Cholic acid

Cholic acid is a lipid of Sterol Lipids (ST) class. Cholic acid is associated with abnormalities such as Cholestasis, Intrahepatic Cholestasis, Atherosclerosis, Diabetes and cholesterol gallstones. The involved functions are known as Homeostasis, Enterohepatic Circulation, Proliferation (morphologic abnormality), Process and Cell Proliferation. Cholic acid often locates in Hepatic, Cytoplasmic matrix, Membrane, Protoplasm and Tissue membrane. The associated genes with Cholic acid are CYP27A1 gene, ABCB11 gene, NR5A2 gene, SLC10A2 gene and SLC10A1 gene. The related lipids are ursocholic acid, Steroids, Cholestenes, Cholestanes and cholanic acid.

References related to functions published in J. Lipid Res.

PMID	Journal	Published Date	Author	Title
12588951	J. Lipid Res.	2003	Lyons MA et al.	Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice.
20671298	J. Lipid Res.	2010	Zhang Y and Klaassen CD	Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice.
19965603	J. Lipid Res.	2010	Cho JY et al.	Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge.
17332599	J. Lipid Res.	2007	Cuesta de Juan S et al.	Ontogenic development-associated changes in the expression of genes involved in rat bile acid homeostasis.
22021638	J. Lipid Res.	2012	Ridlon JM and Hylemon PB	Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7α-dehydroxylating intestinal bacterium.
17720959	J. Lipid Res.	2007	Kim I et al.	Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine.
16327028	J. Lipid Res.	2006	Marschall HU et al.	Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids.
15210844	J. Lipid Res.	2004	Ishimori N et al.	Quantitative trait loci that determine plasma lipids and obesity in C57BL/6J and 129S1/SvImJ inbred mice.