Lysophosphatidylcholine

Lysophosphatidylcholine is a lipid of Glycerophospholipids (GP) class. Lysophosphatidylcholine is associated with abnormalities such as Ischemia, Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Fatty Liver and Atherosclerosis. The involved functions are known as Inflammation, antagonists, Signal Transduction, Signal Pathways and Saturated. Lysophosphatidylcholine often locates in Body tissue, Head, integral to membrane, Membrane and Extracellular. The associated genes with Lysophosphatidylcholine are RHOA gene, Homologous Gene, GPR4 gene, GPR68 gene and TRPV2 gene. The related lipids are Nonesterified Fatty Acids, lysophosphatidylethanolamine, Lysophosphatidylcholines, Phosphatidylserines and 25-hydroxycholesterol. The related experimental models are Knock-out and Disease model.

References related to genes published in J. Lipid Res.

PMID	Journal	Published Date	Author	Title
25510248	J. Lipid Res.	2015	Takahashi H et al.	Metabolomics reveal 1-palmitoyl lysophosphatidylcholine production by peroxisome proliferator-activated receptor α.
27049024	J. Lipid Res.	2016	Hirsova P et al.	Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis.
26839333	J. Lipid Res.	2016	Fernandez-Ruiz I et al.	Differential lipid metabolism in monocytes and macrophages: influence of cholesterol loading.
25713101	J. Lipid Res.	2015	Siddiqi S and Mansbach CM	Dietary and biliary phosphatidylcholine activates PKCζ in rat intestine.
21908646	J. Lipid Res.	2011	Hollie NI and Hui DY	Group 1B phospholipase A₂ deficiency protects against diet-induced hyperlipidemia in mice.
20610733	J. Lipid Res.	2010	Riederer M et al.	Acyl chain-dependent effect of lysophosphatidylcholine on endothelial prostacyclin production.
19805624	J. Lipid Res.	2010	Yang X et al.	Secretory phospholipase A2 type III enhances alpha-secretase-dependent amyloid precursor protein processing through alterations in membrane fluidity.