7-Ketocholesterol
7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
References related to genes published in J. Lipid Res.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 9548582 | J. Lipid Res. | 1998 | Hakamata H et al. | Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein. |
| 10484610 | J. Lipid Res. | 1999 | Gelissen IC et al. | Oxysterol efflux from macrophage foam cells: the essential role of acceptor phospholipid. |
| 12235181 | J. Lipid Res. | 2002 | Liu Q et al. | Omega-carboxyl variants of 7-ketocholesteryl esters are ligands for beta(2)-glycoprotein I and mediate antibody-dependent uptake of oxidized LDL by macrophages. |
| 21411718 | J. Lipid Res. | 2011 | Heo GY et al. | Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells. |
| 21518695 | J. Lipid Res. | 2011 | Jiang X et al. | A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma. |
| 15995174 | J. Lipid Res. | 2005 | Freeman NE et al. | Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages. |
| 24190732 | J. Lipid Res. | 2014 | Lin N et al. | Determination of 7-ketocholesterol in plasma by LC-MS for rapid diagnosis of acid SMase-deficient Niemann-Pick disease. |
| 18614816 | J. Lipid Res. | 2008 | Freeman-Anderson NE et al. | Cannabinoid (CB2) receptor deficiency reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis. |
| 26239048 | J. Lipid Res. | 2015 | Pajares S et al. | Cholestane-3β,5α,6β-triol: high levels in Niemann-Pick type C, cerebrotendinous xanthomatosis, and lysosomal acid lipase deficiency. |
| 26026069 | J. Lipid Res. | 2015 | Davis S et al. | α-Tocopherols modify the membrane dipole potential leading to modulation of ligand binding by P-glycoprotein. |
| 24927729 | J. Lipid Res. | 2014 | Tempel W et al. | Structural characterization of human cholesterol 7α-hydroxylase. |