Cholic acid
Cholic acid is a lipid of Sterol Lipids (ST) class. Cholic acid is associated with abnormalities such as Cholestasis, Intrahepatic Cholestasis, Atherosclerosis, Diabetes and cholesterol gallstones. The involved functions are known as Homeostasis, Enterohepatic Circulation, Proliferation (morphologic abnormality), Process and Cell Proliferation. Cholic acid often locates in Hepatic, Cytoplasmic matrix, Membrane, Protoplasm and Tissue membrane. The associated genes with Cholic acid are CYP27A1 gene, ABCB11 gene, NR5A2 gene, SLC10A2 gene and SLC10A1 gene. The related lipids are ursocholic acid, Steroids, Cholestenes, Cholestanes and cholanic acid.
References related to genes published in J. Lipid Res.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 12588951 | J. Lipid Res. | 2003 | Lyons MA et al. | Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice. |
| 20671298 | J. Lipid Res. | 2010 | Zhang Y and Klaassen CD | Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice. |
| 19965603 | J. Lipid Res. | 2010 | Cho JY et al. | Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge. |
| 16763287 | J. Lipid Res. | 2006 | Sehayek E et al. | Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprit. |
| 17332599 | J. Lipid Res. | 2007 | Cuesta de Juan S et al. | Ontogenic development-associated changes in the expression of genes involved in rat bile acid homeostasis. |
| 16269825 | J. Lipid Res. | 2006 | Shih DM et al. | A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids. |
| 16534140 | J. Lipid Res. | 2006 | Yamaguchi H et al. | Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3. |
| 23018617 | J. Lipid Res. | 2012 | Létourneau D et al. | StAR-related lipid transfer domain protein 5 binds primary bile acids. |
| 22021638 | J. Lipid Res. | 2012 | Ridlon JM and Hylemon PB | Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7α-dehydroxylating intestinal bacterium. |
| 17720959 | J. Lipid Res. | 2007 | Kim I et al. | Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. |