Sphinganine

Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.

References related to lipids published in J. Lipid Res.


PMIDJournalPublished DateAuthorTitle
9788256J. Lipid Res.1998Yano M et al.Quantitative analysis of ceramide molecular species by high performance liquid chromatography.
12777464J. Lipid Res.2003Dragusin M et al.Metabolism of the unnatural anticancer lipid safingol, L-threo-dihydrosphingosine, in cultured cells.
12897185J. Lipid Res.2003Lieser B et al.Quantification of sphingosine and sphinganine from crude lipid extracts by HPLC electrospray ionization tandem mass spectrometry.
19369694J. Lipid Res.2009Hu W et al.Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.
20228220J. Lipid Res.2010Scherer M et al.A rapid and quantitative LC-MS/MS method to profile sphingolipids.
21415121J. Lipid Res.2011Momin AA et al.A method for visualization of "omic" datasets for sphingolipid metabolism to predict potentially interesting differences.
20660127J. Lipid Res.2010Hammad SM et al.Blood sphingolipidomics in healthy humans: impact of sample collection methodology.
19144995J. Lipid Res.2009Hamai H et al.Defective CFTR increases synthesis and mass of sphingolipids that modulate membrane composition and lipid signaling.
18359959J. Lipid Res.2008Masukawa Y et al.Characterization of overall ceramide species in human stratum corneum.
18263851J. Lipid Res.2008Oda M et al.The relationship between the metabolism of sphingomyelin species and the hemolysis of sheep erythrocytes induced by Clostridium perfringens alpha-toxin.
16639079J. Lipid Res.2006Masukawa Y et al.Liquid chromatography-mass spectrometry for comprehensive profiling of ceramide molecules in human hair.
13130120J. Lipid Res.2004Fyrst H et al.Characterization of free endogenous C14 and C16 sphingoid bases from Drosophila melanogaster.
12639977J. Lipid Res.2003Hoekstra D et al.Membrane dynamics and cell polarity: the role of sphingolipids.