25-Hydroxycholesterol

25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.

References related to lipids published in J. Lipid Res.


PMIDJournalPublished DateAuthorTitle
11590225J. Lipid Res.2001Panini SR et al.Arachidonate metabolism and the signaling pathway of induction of apoptosis by oxidized LDL/oxysterol.
11792719J. Lipid Res.2002Hayden JM et al.Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol.
21652732J. Lipid Res.2011Diczfalusy U and Björkhem IStill another activity by the highly promiscuous enzyme CYP3A4: 25-hydroxylation of cholesterol.
19502589J. Lipid Res.2009Diczfalusy U et al.Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide.
19812052J. Lipid Res.2010Schüle R et al.Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.
17890683J. Lipid Res.2007Li X et al.Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta,25-diol 3-sulfate, in hepatocytes.
17586788J. Lipid Res.2007Lee PC et al.Amplification of the gene for SCAP, coupled with Insig-1 deficiency, confers sterol resistance in mutant Chinese hamster ovary cells.
12454275J. Lipid Res.2002Meaney S et al.On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function.
26497473J. Lipid Res.2015Iaea DB et al.A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol.
24891333J. Lipid Res.2014Sekiya M et al.Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.