7-Dehydrocholesterol
7-Dehydrocholesterol is a lipid of Sterol Lipids (ST) class. 7-dehydrocholesterol is associated with abnormalities such as Dehydration, Exanthema, RETINITIS PIGMENTOSA 49, Congenital Abnormality and Failure to Thrive. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Mutation, Lysis, Anabolism and Biosynthetic Pathways. 7-dehydrocholesterol often locates in Plasma membrane, Body tissue, Tissue membrane, Membrane and outer membrane. The associated genes with 7-Dehydrocholesterol are mutant gene, THEMIS gene, IGKV1D-37 gene, LGALS4 gene and Orthologous Gene. The related lipids are Membrane Lipids, Steroids, Sterols, campesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out and Rodent Model.
References related to lipids published in J. Lipid Res.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 10428990 | J. Lipid Res. | 1999 | Honda A et al. | Bile acid synthesis in the Smith-Lemli-Opitz syndrome: effects of dehydrocholesterols on cholesterol 7alpha-hydroxylase and 27-hydroxylase activities in rat liver. |
| 20702862 | J. Lipid Res. | 2010 | Korade Z et al. | Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome. |
| 21402677 | J. Lipid Res. | 2011 | Xu L et al. | An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome. |
| 16258167 | J. Lipid Res. | 2006 | Tulenko TN et al. | A membrane defect in the pathogenesis of the Smith-Lemli-Opitz syndrome. |
| 23828810 | J. Lipid Res. | 2013 | Windsor K et al. | Probing lipid-protein adduction with alkynyl surrogates: application to Smith-Lemli-Opitz syndrome. |
| 23381570 | J. Lipid Res. | 2013 | Xu L et al. | Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells. |
| 24259532 | J. Lipid Res. | 2014 | Liu W et al. | A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome. |
| 25017465 | J. Lipid Res. | 2014 | Goyal S et al. | Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1. |
| 18344409 | J. Lipid Res. | 2008 | Boesze-Battaglia K et al. | Alteration of retinal rod outer segment membrane fluidity in a rat model of Smith-Lemli-Opitz syndrome. |
| 14594996 | J. Lipid Res. | 2004 | Keller RK et al. | Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome. |