7-Dehydrocholesterol

7-Dehydrocholesterol is a lipid of Sterol Lipids (ST) class. 7-dehydrocholesterol is associated with abnormalities such as Dehydration, Exanthema, RETINITIS PIGMENTOSA 49, Congenital Abnormality and Failure to Thrive. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Mutation, Lysis, Anabolism and Biosynthetic Pathways. 7-dehydrocholesterol often locates in Plasma membrane, Body tissue, Tissue membrane, Membrane and outer membrane. The associated genes with 7-Dehydrocholesterol are mutant gene, THEMIS gene, IGKV1D-37 gene, LGALS4 gene and Orthologous Gene. The related lipids are Membrane Lipids, Steroids, Sterols, campesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out and Rodent Model.

References related to experimental models published in J. Lipid Res.


PMIDJournalPublished DateAuthorTitle
21402677J. Lipid Res.2011Xu L et al.An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome.
23381570J. Lipid Res.2013Xu L et al.Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells.
25017465J. Lipid Res.2014Goyal S et al.Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.
14594996J. Lipid Res.2004Keller RK et al.Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.