rotenone is a lipid of Polyketides (PK) class. Rotenone is associated with abnormalities such as Parkinson Disease, MYOPATHY, DISTAL, WITH ANTERIOR TIBIAL ONSET, Neurodegenerative Disorders, Septicemia and Respiratory Failure. The involved functions are known as Phosphorylation, Process, Cell Death, proteasome activity and Apoptosis. Rotenone often locates in Protoplasm, Presynaptic Terminals, Neurites, NADH dehydrogenase complex and Mitochondria. The associated genes with rotenone are DNAJB9 gene, EIF2S3 gene, Candidate Disease Gene, G-substrate and ERN1 gene. The related lipids are Lipopolysaccharides, Membrane Lipids, Phosphatidylserines, Fatty Acids and Cardiolipins. The related experimental models are Knock-out, Mouse Model, Disease model and Rodent Model.
PMID | Journal | Published Date | Author | Title |
---|---|---|---|---|
8656275 | J. Neurosci. | 1996 | Higgins DS and Greenamyre JT | [3H]dihydrorotenone binding to NADH: ubiquinone reductase (complex I) of the electron transport chain: an autoradiographic study. |
9852565 | J. Neurosci. | 1998 | Castilho RF et al. | Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells. |
11717342 | J. Neurosci. | 2001 | Chen X et al. | Opioid receptor modulation of a metabolically sensitive ion channel in rat amygdala neurons. |
11826108 | J. Neurosci. | 2002 | Gao HM et al. | Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons. |
11306608 | J. Neurosci. | 2001 | Hernandez-Guijo JM et al. | Calcium-dependent inhibition of L, N, and P/Q Ca2+ channels in chromaffin cells: role of mitochondria. |
12598611 | J. Neurosci. | 2003 | Gao HM et al. | Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease. |
12486162 | J. Neurosci. | 2002 | Ryu EJ et al. | Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. |
12867501 | J. Neurosci. | 2003 | Gao HM et al. | Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons. |
11124972 | J. Neurosci. | 2000 | Tretter L and Adam-Vizi V | Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress. |
12177198 | J. Neurosci. | 2002 | Sherer TB et al. | An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. |
14645467 | J. Neurosci. | 2003 | Sherer TB et al. | Mechanism of toxicity in rotenone models of Parkinson's disease. |
15356189 | J. Neurosci. | 2004 | Starkov AA et al. | Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. |
19741132 | J. Neurosci. | 2009 | Ng CH et al. | Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila. |
19074024 | J. Neurosci. | 2008 | Rojas JC et al. | Neuroprotective effects of near-infrared light in an in vivo model of mitochondrial optic neuropathy. |
19625511 | J. Neurosci. | 2009 | Saha S et al. | LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. |
17611283 | J. Neurosci. | 2007 | Yadava N and Nicholls DG | Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone. |
15574738 | J. Neurosci. | 2004 | Hongpaisan J et al. | Strong calcium entry activates mitochondrial superoxide generation, upregulating kinase signaling in hippocampal neurons. |
15574749 | J. Neurosci. | 2004 | Coulom H and Birman S | Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster. |
16251452 | J. Neurosci. | 2005 | Bao L et al. | Partial mitochondrial inhibition causes striatal dopamine release suppression and medium spiny neuron depolarization via H2O2 elevation, not ATP depletion. |
15673665 | J. Neurosci. | 2005 | Allen NJ et al. | A preferential role for glycolysis in preventing the anoxic depolarization of rat hippocampal area CA1 pyramidal cells. |
16641227 | J. Neurosci. | 2006 | Hsuan SL et al. | Basic fibroblast growth factor protects against rotenone-induced dopaminergic cell death through activation of extracellular signal-regulated kinases 1/2 and phosphatidylinositol-3 kinase pathways. |
16624952 | J. Neurosci. | 2006 | Jiang Q et al. | Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism. |
17005863 | J. Neurosci. | 2006 | Malagelada C et al. | RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation. |
18463239 | J. Neurosci. | 2008 | Press C and Milbrandt J | Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress. |
18685029 | J. Neurosci. | 2008 | Costa C et al. | Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition. |
18716221 | J. Neurosci. | 2008 | Hayashi Y et al. | Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice. |
24305821 | J. Neurosci. | 2013 | Persson AK et al. | Sodium channels contribute to degeneration of dorsal root ganglion neurites induced by mitochondrial dysfunction in an in vitro model of axonal injury. |